文章：

层粘连蛋白在肺癌及DNA损伤应答中的多重作用

The Multifaceted Roles of Lamins in Lung Cancer and DNA Damage Response

原文发布日期：21 November 2023

DOI: 10.3390/cancers15235501

类型: Article

开放获取: 是

英文摘要：

Emerging evidence suggests that lamin functions are not limited to maintaining the structural integrity of the nucleus in eukaryotic cells but that these functions affect many facets of cancer biology. An increasing number of reports suggest that adaptive changes in the lamin subtype composition within the nuclear lamina could affect essential features of cancer development and aggressiveness. These include regulation of cellular stiffness and mobility as well as epithelial-to-mesenchymal transition (EMT), all of which directly impact the metastatic properties of cancer cells. Additionally, insights from studies on the physiological functions of lamins suggest that cancer cells could hijack the ability of lamins to modify chromatin accessibility, cell cycle regulation, and DNA damage response. Here, we present a comprehensive overview of the role of lamins in lung cancer and DNA damage response, which is commonly evoked by lung cancer therapies. Collectively, this information should help better understand the sometimes-conflicting reports on lamin functions in lung cancer as well as in other cancer types.

摘要翻译： 

新兴证据表明，核纤层蛋白的功能不仅限于维持真核细胞核的结构完整性，还深刻影响着癌症生物学的多个层面。越来越多的研究指出，核纤层内部核纤层蛋白亚型组成的适应性变化可能影响癌症发生与侵袭性的关键特征，包括细胞硬度与运动性的调控以及上皮-间质转化过程，这些因素均直接影响癌细胞的转移特性。此外，对核纤层蛋白生理功能的研究揭示，癌细胞可能劫持其调控染色质可及性、细胞周期及DNA损伤应答的能力。本文系统综述了核纤层蛋白在肺癌及DNA损伤应答中的作用机制，后者常由肺癌治疗手段所引发。整合这些信息将有助于更清晰地理解当前关于核纤层蛋白在肺癌及其他癌症类型中功能研究的争议性发现。

原文链接：

The Multifaceted Roles of Lamins in Lung Cancer and DNA Damage Response