The Hippo pathway is conserved across species. Key mammalian Hippo pathway kinases, including MST1/2 and LATS1/2, inhibit cellular growth by inactivating the TEAD coactivators, YAP, and TAZ. Extensive research has illuminated the roles of Hippo signaling in cancer, development, and regeneration. Notably, dysregulation of Hippo pathway components not only contributes to tumor growth and metastasis, but also renders tumors resistant to therapies. This review delves into recent research on YAP/TAZ-TEAD-mediated gene regulation and biological processes in cancer. We focus on several key areas: newly identified molecular patterns of YAP/TAZ activation, emerging mechanisms that contribute to metastasis and cancer therapy resistance, unexpected roles in tumor suppression, and advances in therapeutic strategies targeting this pathway. Moreover, we provide an updated view of YAP/TAZ’s biological functions, discuss ongoing controversies, and offer perspectives on specific debated topics in this rapidly evolving field.
Hippo信号通路在物种间高度保守。其核心哺乳动物激酶MST1/2和LATS1/2通过抑制TEAD共激活因子YAP与TAZ的活性来调控细胞生长。大量研究已揭示该通路在癌症发生、发育及再生过程中的重要作用。值得注意的是，Hippo通路组分的失调不仅促进肿瘤生长与转移，还会导致肿瘤产生治疗抵抗。本综述系统探讨了YAP/TAZ-TEAD介导的基因调控在癌症中的最新研究进展，重点关注以下关键领域：新发现的YAP/TAZ激活分子模式、促进转移与治疗抵抗的新机制、该通路在肿瘤抑制中的意外功能，以及针对该通路的治疗策略进展。此外，我们更新了对YAP/TAZ生物学功能的认识，探讨了当前存在的学术争议，并对这一快速发展领域中的特定争议问题提出了新的见解。
New Insights into YAP/TAZ-TEAD-Mediated Gene Regulation and Biological Processes in Cancer
肿瘤(癌症)患者之家