文章：

靶向髓源性抑制细胞迁移：微卫星稳定结直肠癌的新型免疫治疗策略

Targeting Myeloid-Derived Suppressor Cell Trafficking as a Novel Immunotherapeutic Approach in Microsatellite Stable Colorectal Cancer

原文发布日期：20 November 2023

DOI: 10.3390/cancers15225484

类型: Article

开放获取: 是

英文摘要：

Myeloid-derived suppressor cells (MDSCs) are a unique subset of immune cells that promote an immunosuppressive phenotype due to their impacts on CD8 and regulatory T cell function. The inhibition of MDSC trafficking to the tumor microenvironment (TME) may represent a novel target in microsatellite stable (MSS) colorectal cancer with the potential to reprogram the immune system. Here, we review the rationale of inhibiting myeloid suppressor cell trafficking in treatment-refractory MSS colorectal cancer and circulating tumor DNA (ctDNA) positive settings to determine whether this approach can serve as a backbone for promoting immunotherapy response in this difficult-to-treat disease.

摘要翻译： 

髓源性抑制细胞（MDSCs）是一类独特的免疫细胞亚群，因其对CD8细胞和调节性T细胞功能的影响而表现出免疫抑制表型。抑制MDSCs向肿瘤微环境（TME）的迁移，可能成为微卫星稳定（MSS）型结直肠癌治疗的新靶点，并具有重塑免疫系统的潜力。本文综述了在治疗难治性MSS结直肠癌及循环肿瘤DNA（ctDNA）阳性背景下，抑制髓系抑制细胞迁移的理论依据，旨在探讨该策略能否作为促进这类难治性疾病免疫治疗应答的基础方案。

原文链接：

Targeting Myeloid-Derived Suppressor Cell Trafficking as a Novel Immunotherapeutic Approach in Microsatellite Stable Colorectal Cancer