文章：

神经内分泌肿瘤患者静脉血栓栓塞的风险

The Risk of Venous Thromboembolism in Neuroendocrine Neoplasms

原文发布日期：20 November 2023

DOI: 10.3390/cancers15225477

类型: Article

开放获取: 是

英文摘要：

Neuroendocrine neoplasms (NENs) differ from other malignancies in their ability to produce hormones and biogenic amines, as well as offer a better prognosis in well-differentiated tumors. There are no definite data on the occurrence of thromboembolic events in NENs and no recommendations regarding the use of antithrombotic prophylaxis in this group. Accurate assessment of the thromboembolic risk in NENs represents an important issue, in order to reduce morbidity and mortality due to complications of VTE. The aim of this work was to review the occurrence of thromboembolic events in NENs and the use of antithrombotic prophylaxis in this group. A total of 28 studies identified on PubMed were analyzed. NENs, especially of pancreatic primary, exhibit an increased thrombotic risk. Atypical VTE locations are quite common in NENs. Hormonally active NENs are associated with a significantly increased thromboembolic risk. Further studies in NENs are needed to evaluate the parameters of coagulation and fibrinolysis as predictive biomarkers for VTE complications.

摘要翻译： 

神经内分泌肿瘤（NENs）与其他恶性肿瘤的区别在于其能够产生激素和生物胺，且分化良好的肿瘤预后更佳。目前关于NENs患者血栓栓塞事件发生率尚无明确数据，亦无针对该人群抗血栓预防的具体建议。准确评估NENs患者的血栓栓塞风险至关重要，这有助于降低静脉血栓栓塞并发症导致的发病率和死亡率。本文旨在系统综述NENs患者血栓栓塞事件的发生情况及其抗血栓预防措施的应用。通过分析PubMed数据库收录的28项研究，发现NENs（尤其是胰腺原发肿瘤）具有较高的血栓形成风险，非典型部位静脉血栓栓塞在NENs中较为常见，激素活性型NENs与显著升高的血栓栓塞风险相关。未来需要进一步开展研究，评估凝血与纤溶系统参数作为预测NENs患者静脉血栓栓塞并发症的生物标志物价值。

原文链接：

The Risk of Venous Thromboembolism in Neuroendocrine Neoplasms