文章：

从非酒精性脂肪性肝炎（NASH）到肝细胞癌（HCC）：流行病学、发病率、预测、风险因素与预防

From Non-Alcoholic Steatohepatitis (NASH) to Hepatocellular Carcinoma (HCC): Epidemiology, Incidence, Predictions, Risk Factors, and Prevention

原文发布日期：17 November 2023

DOI: 10.3390/cancers15225458

类型: Article

开放获取: 是

英文摘要：

Non-alcoholic fatty liver disease (NAFLD) affects up to a quarter of the adult population in many developed and developing countries. This spectrum of liver disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) and cirrhosis. The incidence of NASH is projected to increase by up to 56% over the next 10 years. There is growing epidemiological evidence that NAFLD has become the fastest-growing cause of hepatocellular carcinoma (HCC) in industrialized countries. The annual incidence of HCC varies between patients with NASH cirrhosis and patients with noncirrhotic NAFLD. In this review, NAFLD/NASH-associated HCC will be described, including its epidemiology, risk factors promoting hepatocarcinogenesis, and management of HCC in patients with obesity and associated metabolic comorbidities, including preventive strategies and therapeutic approaches to address this growing problem.

摘要翻译： 

非酒精性脂肪性肝病（NAFLD）影响着许多发达国家和发展中国家高达四分之一的成年人口。这一系列肝脏疾病涵盖从单纯性脂肪变性到非酒精性脂肪性肝炎（NASH）及肝硬化的不同阶段。预计未来十年内NASH发病率将增长高达56%。越来越多的流行病学证据表明，在工业化国家中，NAFLD已成为肝细胞癌（HCC）增长最快的致病因素。NASH肝硬化患者与非肝硬化NAFLD患者的HCC年发病率存在差异。本综述将系统阐述NAFLD/NASH相关肝细胞癌，包括其流行病学特征、促进肝癌发生的风险因素，以及在肥胖及相关代谢共病患者中HCC的防治策略——涵盖针对这一日益严峻问题的预防措施与治疗方案。

原文链接：

From Non-Alcoholic Steatohepatitis (NASH) to Hepatocellular Carcinoma (HCC): Epidemiology, Incidence, Predictions, Risk Factors, and Prevention