文章：

确定胰腺癌所致总胆固醇与肥胖相关因素用于制定运动干预方案的最佳临界值：基于国民健康保险共享服务数据的大数据分析

Determining Optimal Cut-Off Value of Pancreatic-Cancer-Induced Total Cholesterol and Obesity-Related Factors for Developing Exercise Intervention: Big Data Analysis of National Health Insurance Sharing Service Data

原文发布日期：16 November 2023

DOI: 10.3390/cancers15225444

类型: Article

开放获取: 是

英文摘要：

This study aimed to examine the effects of multiple parameters on the incidence of pancreatic cancer. We analyzed data from 1,108,369 individuals in the National Health Insurance Sharing Service Database (NHISS DB; birth to death; 2002 to 2015) and identified 2912 patients with pancreatic cancer. Body mass index, systolic/diastolic blood pressure, and fasting blood glucose and total cholesterol concentrations were lower in women with than without pancreatic cancer (p< 0.01). Fasting blood glucose and total cholesterol concentrations were significantly different between men with and without pancreatic cancer (p< 0.05). In the logistic regression analysis, the total cholesterol concentration (odds ratio (OR), 1.007; 95% confidence interval (CI), 1.005–1.010) was significantly higher in men than women with pancreatic cancer (p< 0.05). Pancreatic cancer rates were highest in men who smoked for 5–9 years or more (OR, 5.332) and in women who smoked for 10–19 years (OR, 18.330). Daily intensive exercise reduced the risk of pancreatic cancer by 56% in men (95% CI, 0.230–0.896). Receiver operating characteristic curve analysis revealed a total cholesterol concentration cut-off point of 188.50 mg/dL (p< 0.05) in men with pancreatic cancer, with a sensitivity and specificity of 53.5% and 54.6%, respectively. For women, the cut-off values for weight and gamma glutamyl transpeptidase concentration were 58.5 kg and 20.50 U/L, respectively. The sex-specific differences in patients with pancreatic cancer identified herein will aid in the development of individualized evidence-based prognostic and preventive programs for the treatment of pancreatic cancer.

摘要翻译： 

本研究旨在探讨多种参数对胰腺癌发病率的影响。我们分析了国民健康保险共享服务数据库（NHISS DB；2002年至2015年，涵盖出生至死亡数据）中1,108,369名个体的数据，共识别出2912例胰腺癌患者。分析显示，女性胰腺癌患者的体重指数、收缩压/舒张压、空腹血糖及总胆固醇浓度均显著低于非胰腺癌女性（p<0.01）。男性胰腺癌患者与非胰腺癌患者的空腹血糖和总胆固醇浓度存在显著差异（p<0.05）。逻辑回归分析表明，男性胰腺癌患者的总胆固醇浓度显著高于女性患者（比值比（OR）为1.007；95%置信区间（CI）为1.005–1.010；p<0.05）。胰腺癌发病率在吸烟5–9年及以上的男性（OR为5.332）和吸烟10–19年的女性（OR为18.330）中最高。每日高强度运动可使男性患胰腺癌的风险降低56%（95% CI为0.230–0.896）。受试者工作特征曲线分析显示，男性胰腺癌患者的总胆固醇浓度临界值为188.50 mg/dL（p<0.05），敏感性和特异性分别为53.5%和54.6%。对于女性患者，体重和γ-谷氨酰转肽酶浓度的临界值分别为58.5 kg和20.50 U/L。本研究揭示的胰腺癌患者性别特异性差异，将有助于制定个体化、循证为基础的胰腺癌治疗预后及预防方案。

原文链接：

Determining Optimal Cut-Off Value of Pancreatic-Cancer-Induced Total Cholesterol and Obesity-Related Factors for Developing Exercise Intervention: Big Data Analysis of National Health Insurance Sharing Service Data