Prostate cancer (PC) is the second most common type of cancer and the leading cause of death among men worldwide. Preventing the progression of cancer after treatments such as radical prostatectomy, radiation therapy, and hormone therapy is a major concern faced by prostate cancer patients. Inflammation, which can be caused by various factors such as infections, the microbiome, obesity and a high-fat diet, is considered to be the main cause of PC. Inflammatory cells are believed to play a crucial role in tumor progression. Therefore, nonsteroidal anti-inflammatory drugs along with their effects on the treatment of inflammation-related diseases, can prevent cancer and its progression by suppressing various inflammatory pathways. Recent evidence shows that nonsteroidal anti-inflammatory drugs are effective in the prevention and treatment of prostate cancer. In this review, we discuss the different pathways through which these drugs exert their potential preventive and therapeutic effects on prostate cancer.
前列腺癌是全球范围内男性中第二常见的癌症类型，也是导致男性死亡的主要原因。在根治性前列腺切除术、放射治疗和激素治疗等干预措施后，如何防止癌症进展是前列腺癌患者面临的主要问题。由感染、微生物群、肥胖及高脂饮食等多种因素引发的炎症被认为是前列腺癌发生的主要诱因。炎症细胞在肿瘤进展过程中被认为发挥着关键作用。因此，非甾体抗炎药除了对炎症相关疾病的治疗作用外，还能通过抑制多种炎症通路来预防癌症及其进展。最新证据表明，非甾体抗炎药在前列腺癌的预防和治疗中具有显著效果。本文综述了这类药物在前列腺癌防治中发挥潜在作用的不同作用通路。
The Potential Preventive and Therapeutic Roles of NSAIDs in Prostate Cancer
肿瘤(癌症)患者之家