Significant relationships with endometrial cancer were demonstrated, both forCCL2,CCL5, andCXCL8chemokines and for the chemokine receptorCXCR2. The reported case-control study of genetic associations was designed to establish the role of selected single nucleotide polymorphisms (SNPs) of theCCL2,CCL5,CXCL8, andCXCR2genes in the onset and progression of endometrial cancer. This study was conducted on 282 women, including 132 (46.8%) patients with endometrial cancer and 150 (53.2%) non-cancerous controls. The genotypes forCCL2rs4586,CCL5rs2107538 and rs2280789,CXCL8rs2227532 and −738 T>A, andCXCR2rs1126580 were determined, using PCR-RFLP assays. The AA homozygotes inCCL5rs2107538 were associated with more than a quadruple risk of endometrial cancer (p≤ 0.050). The GA heterozygotes in theCXCR2SNP were associated with approximately threefold higher cancer risk (p≤ 0.001). That association also remained significant after certain adjustments, carried out for age, diabetes mellitus, arterial hypertension, or endometrial thickness above 5 mm (p≤ 0.050). The A-A haplotypes for theCCL5polymorphisms and T-A-A haplotypes for theCCL2andCCL5SNPs were associated with about a twofold risk of endometrial cancer (p≤ 0.050). In conclusion,CCL2rs4586,CCL5rs2107538 and rs2280789, andCXCR2rs1126580 demonstrated significant associations with an increased risk of endometrial cancer.
研究证实，趋化因子CCL2、CCL5、CXCL8及其受体CXCR2与子宫内膜癌存在显著相关性。本病例对照研究旨在探讨CCL2、CCL5、CXCL8和CXCR2基因特定单核苷酸多态性（SNPs）在子宫内膜癌发生发展中的作用。研究纳入282名女性，其中子宫内膜癌患者132例（46.8%），非癌对照组150例（53.2%）。采用PCR-RFLP方法检测了CCL2 rs4586、CCL5 rs2107538与rs2280789、CXCL8 rs2227532与-738 T>A以及CXCR2 rs1126580的基因型。结果显示：CCL5 rs2107538位点的AA纯合子基因型使子宫内膜癌风险增加四倍以上（p≤0.050）；CXCR2 SNP的GA杂合子基因型使癌症风险提升约三倍（p≤0.001），该关联在校正年龄、糖尿病、动脉高血压或子宫内膜厚度＞5 mm等因素后仍保持显著（p≤0.050）；CCL5多态性的A-A单倍型及CCL2与CCL5 SNPs的T-A-A单倍型均使癌症风险增加约两倍（p≤0.050）。结论：CCL2 rs4586、CCL5 rs2107538与rs2280789以及CXCR2 rs1126580多态性与子宫内膜癌风险升高存在显著关联。
肿瘤(癌症)患者之家