文章：

多发性脑转移瘤立体定向放射外科治疗技术综述

Stereotactic Radiosurgery of Multiple Brain Metastases: A Review of Treatment Techniques

原文发布日期：14 November 2023

DOI: 10.3390/cancers15225404

类型: Article

开放获取: 是

英文摘要：

The advancement of systemic targeted treatments has led to improvements in the management of metastatic disease, particularly in terms of survival outcomes. However, brain metastases remain less responsive to systemic therapies, underscoring the significance of local interventions for comprehensive disease control. Over the past years, the threshold for treating brain metastases through stereotactic radiosurgery has risen. Yet, as the number of treated metastases increases, treatment complexity and duration also escalate. This trend has made multi-isocenter radiosurgery treatments, such as those with the Gamma Knife, challenging to plan and lengthy for patients. In contrast, single-isocenter approaches employing linear accelerators offer an efficient and expeditious treatment option. This review delves into the literature, comparing different linear-accelerator-based techniques with each other and in relation to dedicated systems, focusing on dosimetric considerations and feasibility.

摘要翻译： 

系统性靶向治疗的进步已显著改善了转移性疾病的治疗管理，尤其在生存结局方面取得了积极进展。然而，脑转移瘤对系统性治疗的反应仍相对有限，这凸显了局部干预在实现全面疾病控制中的重要性。近年来，通过立体定向放射外科治疗脑转移瘤的适应症范围有所扩大。但随着治疗病灶数量的增加，治疗的复杂性和持续时间也随之上升。这一趋势使得多等中心放射外科治疗（如伽玛刀）在计划制定上更具挑战性，且患者治疗时间延长。相比之下，采用直线加速器的单等中心治疗方法提供了一种高效且快速的治疗选择。本综述通过深入分析相关文献，比较了不同基于直线加速器的技术之间及其与专用系统的差异，重点关注剂量学考量和临床可行性。

原文链接：

Stereotactic Radiosurgery of Multiple Brain Metastases: A Review of Treatment Techniques