Leukemia cutis (LC) is defined as the leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding a number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as the genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, the complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis, and treatment of leukemic skin involvement in different types of leukemia.
皮肤白血病（LC）定义为白血病细胞对表皮、真皮及皮下组织的浸润。皮肤白血病可在系统性白血病诊断后出现或与之同时发生，但皮肤病变偶尔也可作为白血病的首发表现。白血病皮肤浸润在病变数量、分布及形态学方面表现出显著差异。皮肤白血病最常见于慢性淋巴细胞白血病、单核细胞及粒单核细胞急性髓系白血病，以及T细胞系白血病。尽管白血病细胞侵犯皮肤的致病机制尚未完全明确，但趋化因子受体、黏附分子以及白血病的遗传特征被认为在其中发挥作用。白血病皮肤病变可呈局限性或播散性，可单独或合并出现于皮肤任何部位，最常见于躯干和四肢。皮肤白血病最常见的临床表现包括丘疹、结节、斑疹、斑块和溃疡。在多数患者中，皮肤浸润的完全或部分消退与血液学缓解同步发生。然而，对于耐药性疾病或皮肤浸润复发的患者，可采用局部放射治疗。本综述将呈现不同类型白血病皮肤受累的发病机制、诊断及治疗的最新研究数据。
Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment
肿瘤(癌症)患者之家