Background: There are several significant gaps in current studies of the relationship between anti-cancer medications and orthodontic care that call for more investigation. As a result, the main goals of this systematic review and meta-analysis were to summarise and assess the information that was available regarding the effect of radiotherapy and anti-cancer medications on the overall successful completion of an orthodontic treatment plan. Methods: A standardised data extraction form was devised in accordance with the PRISMA guidelines to conduct a systematic review and meta-analysis, with specific criteria implemented for selecting studies with low to moderate risk of bias. Results: Five studies involving different methodologies were selected at the conclusion of the search strategy. The statistical analysis revealed an estimated odds ratio (OR) of 0.31 and relative risk (RR) of 0.48, indicating a statistically significant association between the use of radiotherapy and anti-neoplastic drugs and a noticeable reduction in the successful completion of orthodontic treatment. The heterogeneity analysis showed significant heterogeneity among the studies. Conclusions: This review emphasises that, although orthodontic therapies can still be beneficial for children receiving chemotherapy, the effectiveness of the therapy may be diminished in older populations. The findings further highlight how crucial it is to take cancer therapies into account when planning and managing orthodontic treatment in order to optimise results and reduce problems.
背景：当前关于抗癌药物与正畸治疗关系的研究存在若干显著空白，亟需进一步深入探讨。因此，本系统性综述与荟萃分析的主要目标是总结并评估现有关于放疗及抗癌药物对正畸治疗计划整体完成成功率影响的证据。方法：依据PRISMA指南设计标准化数据提取表，采用特定标准筛选偏倚风险低至中等的研究进行系统性综述与荟萃分析。结果：通过系统检索策略最终纳入五项采用不同研究方法的相关研究。统计分析显示，放疗与抗肿瘤药物的使用与正畸治疗成功完成率显著降低存在统计学关联，其比值比（OR）估计值为0.31，相对危险度（RR）为0.48。异质性分析表明各研究间存在显著异质性。结论：本综述强调，虽然正畸治疗对接受化疗的儿童患者仍具临床价值，但在年长群体中治疗效果可能减弱。研究结果进一步凸显了在正畸治疗规划与管理中充分考虑癌症治疗方案的重要性，以优化治疗效果并减少并发症。
肿瘤(癌症)患者之家