文章：

吲哚生物碱靶向MAP激酶信号通路在癌症治疗中的研究进展

Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment

原文发布日期：7 November 2023

DOI: 10.3390/cancers15225311

类型: Article

开放获取: 是

英文摘要：

Cancer is the leading cause of morbidity and mortality in people throughout the world. There are many signaling pathways associated with cancerous diseases, from which the Mitogen-activated protein kinase (MAPK) pathway performs a significant role in this regard. Apoptosis and proliferation are correlated with MAPK signaling pathways. Plenty of experimental investigations were carried out to assess the role of indole alkaloids in MAPK-mediated cancerous diseases. Previous reports established that indole alkaloids, such as vincristine and evodiamine are useful small molecules in cancer treatment via the MAPK signaling system. Indole alkaloids have the anticancer potential through different pathways. Vincristine and evodiamine are naturally occurring indole alkaloids that have strong anticancer properties. Additionally, much research is ongoing or completed with molecules belonging to this group. The current review aims to evaluate how indole alkaloids affect the MAPK signaling pathway in cancer treatment. Additionally, we focused on the advancement in the role of indole alkaloids, with the intention of modifying the MAPK signaling pathways to investigate potential new anticancer small molecules. Furthermore, clinical trials with indole alkaloids in cancer treatment are also highlighted.

摘要翻译： 

癌症是全球范围内导致人类发病和死亡的主要原因。多种信号通路与癌症疾病相关，其中丝裂原活化蛋白激酶（MAPK）通路在此过程中发挥着重要作用。细胞凋亡和增殖过程均与MAPK信号通路密切相关。大量实验研究已评估吲哚生物碱在MAPK介导的癌症疾病中的作用。既往研究证实，长春新碱和吴茱萸碱等吲哚生物碱是通过MAPK信号系统治疗癌症的有效小分子。吲哚生物碱通过不同途径发挥抗癌潜力，其中长春新碱和吴茱萸碱作为天然存在的吲哚生物碱具有显著的抗癌特性。目前针对该类分子的研究正在广泛开展或已完成。本综述旨在系统评估吲哚生物碱在癌症治疗中如何影响MAPK信号通路，重点关注该类化合物研究进展，旨在通过调控MAPK信号通路探索潜在的新型抗癌小分子。此外，本文还着重探讨了吲哚生物碱在癌症治疗中的临床试验进展。

原文链接：

Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment