Hodgkin’s lymphoma (HL) is a lymphatic neoplasm typically found in the cervical lymph nodes. The disease is multifactorial, and in recent years, the relationships between various vascular molecules have been explored in the field of vascular biology. The connection between vascular biology and HL is intricate and the roles of several pathways remain unclear. This review summarizes the cellular and molecular relationships between vascular biology and HL. Proteins associated with various functions in vascular biology, including cytokines (TNF-α, IL-1, IL-13, and IL-21), chemokines (CXCL10, CXCL12, and CCL21), adhesion molecules (ELAM-1/VCAM-1), and growth factors (BDNF/NT-3, platelet-derived growth factor receptor-α), have been linked to tumor activity. Notable tumor activities include the induction of paracrine activation of NF-kB-dependent pathways, upregulation of adhesion molecule regulation, genome amplification, and effective loss of antigen presentation mediated by MHC-II. Preclinical study models, primarily those using cell culture, have been optimized for HL. Animal models, particularly mice, are also used as alternatives to complex biological systems, with studies primarily focusing on the physiopathogenic evaluation of the disease. These biomolecules warrant further study because they may shed light on obscure pathways and serve as targets for prevention and/or treatment interventions.
霍奇金淋巴瘤（HL）是一种常见于颈部淋巴结的淋巴系统肿瘤。该疾病具有多因素致病特点，近年来血管生物学领域对多种血管分子间的关联性进行了探索。血管生物学与HL之间的关联错综复杂，多条信号通路的作用机制尚未明确。本综述系统阐述了血管生物学与HL之间的细胞及分子关联机制。研究发现，血管生物学中具有多种功能的相关蛋白——包括细胞因子（TNF-α、IL-1、IL-13和IL-21）、趋化因子（CXCL10、CXCL12和CCL21）、黏附分子（ELAM-1/VCAM-1）以及生长因子（BDNF/NT-3、血小板衍生生长因子受体-α）——均与肿瘤活性存在关联。值得关注的肿瘤活性包括：诱导NF-κB依赖通路的旁分泌激活、上调黏附分子调控机制、基因组扩增以及MHC-II介导的抗原呈递功能失效。目前针对HL的临床前研究模型（主要为细胞培养模型）已得到优化。动物模型（特别是小鼠模型）作为复杂生物系统的替代方案，其研究主要聚焦于疾病的病理生理学评估。这些生物分子值得深入研究，因其可能揭示尚未明确的信号通路，并为预防和/或治疗干预提供潜在靶点。
Potential Associations between Vascular Biology and Hodgkin’s Lymphoma: An Overview
肿瘤(癌症)患者之家