文章：

横纹肌肉瘤：当前疗法、挑战及未来治疗策略展望

Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies

原文发布日期：2 November 2023

DOI: 10.3390/cancers15215269

类型: Article

开放获取: 是

英文摘要：

Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment strategies. Later, we focus on chemotherapy strategies for this childhood sarcoma and discuss the impact of three mechanisms that are involved in the chemotherapy response including apoptosis, macro-autophagy, and the unfolded protein response. Finally, we discuss in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models of rhabdomyosarcoma to screen future therapeutic approaches and promote muscle regeneration.

摘要翻译： 

横纹肌肉瘤是一种起源于骨骼肌的罕见恶性肿瘤，主要影响儿童及青少年。作为儿童健康领域的全球性挑战，转移性与复发性横纹肌肉瘤的治疗效果仍是基础与临床科学家共同关注的核心问题。该疾病的治疗策略主要包括手术切除后联合多药化疗，并视情况辅以电离放射治疗。本综述首先系统阐述横纹肌肉瘤的临床特征，涵盖其分类与亚型、诊断标准及治疗策略；继而聚焦于儿童横纹肌肉瘤的化疗方案，深入探讨细胞凋亡、巨自噬及未折叠蛋白反应三种机制在化疗应答中的作用；最后解析横纹肌肉瘤的体内小鼠/斑马鱼模型与体外三维生物工程模型，为未来治疗策略筛选及肌肉再生研究提供新视角。

原文链接：

Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies