文章：

口腔潜在恶性病变患者唾液生物标志物的初步评估：一项病例对照研究

Preliminary Evaluation Salivary Biomarkers in Patients with Oral Potentially Malignant Disorders (OPMD): A Case–Control Study

原文发布日期：1 November 2023

DOI: 10.3390/cancers15215256

类型: Article

开放获取: 是

英文摘要：

Introduction: Oral potentially malignant disorders (OPMD) are lesions associated with an increased risk of transformation (MT) into cancer. Objective: A study was made of the salivary levels of adenosine deaminase (ADA), ferritin (FRR) and total proteins (TP) in healthy individuals and in patients with oral potentially malignant disorders (OPMD), assessing the potential role of saliva as a diagnostic tool. Methods: A total of 91 subjects participated in the study, divided into two groups—59 patients with OPMD (oral leukoplakia or oral lichen planus) and 32 healthy controls—with measurements being made of salivary ADA, ferritin (FRR) and total proteins (TP). Results: There were no significant differences in salivary mean ADA between the OPMD group 0.85 ± 2.18 UI/I and the controls 0.71 ± 1.72 UI/I (p= 0.934), though the levels of both FRR mean OPMD, 12.66 ± 10.50 (µg/L), versus control, 7.19 ± 4.44 (p= 0.001), and TP, 23.41 ± 17, versus control, 14.15 ± 15.19, were significantly higher in the OPMD group (p= 0.001). Patients with oral lichen planus showed significant differences in terms of FRR (p= 0.009) and TP (p= 0.003). The ferritin in LPO with a cut-off point of 8.5C showed a sensitivity and specificity of 54.3% and 82.3, respectively. The area under the curve (AUC) was 0.69 (95% confidence interval (95% CI): 0.58–0.82;p= 0.003). Conclusions: Ferritin and total proteins may constitute potential salivary biomarkers for oral lichen planus, though further studies are still needed in this field. In addition, saliva testing is a reliable and noninvasive diagnostic tool and appears to be a reliable strategy offering an interesting alternative for the screening of large populations.

摘要翻译： 

引言：口腔潜在恶性病变（OPMD）是指与癌变风险增高相关的口腔病损。本研究旨在探讨健康人群与口腔潜在恶性病变患者唾液中腺苷脱氨酶（ADA）、铁蛋白（FRR）及总蛋白（TP）水平，评估唾液作为诊断工具的潜在价值。方法：共纳入91例研究对象，分为口腔潜在恶性病变组（59例，含口腔白斑或口腔扁平苔藓患者）和健康对照组（32例），检测两组唾液ADA、铁蛋白及总蛋白水平。结果：口腔潜在恶性病变组唾液ADA均值（0.85±2.18 U/L）与对照组（0.71±1.72 U/L）无显著差异（p=0.934）；而铁蛋白（口腔潜在恶性病变组12.66±10.50 μg/L vs 对照组7.19±4.44 μg/L，p=0.001）与总蛋白（口腔潜在恶性病变组23.41±17 g/L vs 对照组14.15±15.19 g/L，p=0.001）水平在口腔潜在恶性病变组显著升高。口腔扁平苔藓患者的铁蛋白（p=0.009）与总蛋白（p=0.003）水平呈现显著差异。以8.5 μg/L为铁蛋白临界值时，其对口腔扁平苔藓的诊断敏感度为54.3%，特异度为82.3%，曲线下面积（AUC）为0.69（95%置信区间：0.58-0.82；p=0.003）。结论：铁蛋白与总蛋白可能成为口腔扁平苔藓的潜在唾液生物标志物，但该领域仍需进一步研究。唾液检测作为可靠无创的诊断工具，有望成为大规模人群筛查的有效策略。

原文链接：

Preliminary Evaluation Salivary Biomarkers in Patients with Oral Potentially Malignant Disorders (OPMD): A Case–Control Study