文章：

多领域筛查：头颈癌治疗前患者风险特征识别

Multi-Domain Screening: Identification of Patient’s Risk Profile Prior to Head-and-Neck Cancer Treatment

原文发布日期：1 November 2023

DOI: 10.3390/cancers15215254

类型: Article

开放获取: 是

英文摘要：

Background: Head-and-neck cancer (HNC) can give rise to oropharyngeal dysphagia (OD), malnutrition, sarcopenia, and frailty. Early identification of these phenomena in newly diagnosed HNC patients is important to reduce the risk of complications and to improve treatment outcomes. The aim of this study was (1) to determine the prevalence of the risk of OD, malnutrition, sarcopenia, and frailty; and (2) to investigate the relation between these phenomena and patients’ age, performance status, and cancer group staging. Methods: Patients (N = 128) underwent multi-domain screening consisting of the Eating Assessment Tool-10 for OD, Short Nutritional Assessment Questionnaire and BMI for malnutrition, Short Physical Performance Battery and Hand Grip Strength for sarcopenia, and Distress Thermometer and Maastricht Frailty Screening Tool for frailty. Results: 26.2%, 31.0%, 73.0%, and 46.4% of the patients were at risk for OD, malnutrition, sarcopenia, or frailty, respectively. Patients with an advanced cancer stage had a significantly higher risk of OD and high levels of distress prior to cancer treatment. Conclusions: This study identified the risk profile of newly diagnosed HNC patients using a standardized ‘quick and easy’ multi-domain screening prior to cancer treatment.

摘要翻译： 

背景：头颈癌可引发口咽性吞咽困难、营养不良、肌肉减少症及衰弱综合征。在新诊断的头颈癌患者中早期识别这些现象，对降低并发症风险及改善治疗结局具有重要意义。本研究旨在：（1）明确口咽性吞咽困难、营养不良、肌肉减少症及衰弱综合征的风险发生率；（2）探究这些现象与患者年龄、体能状态及癌症分期之间的关联。方法：对128例患者进行多维度筛查，包括采用进食评估工具-10筛查口咽性吞咽困难，使用简易营养评估问卷和体重指数评估营养不良风险，通过简易体能状况量表和握力测试检测肌肉减少症，运用痛苦温度计和马斯特里赫特衰弱筛查工具评估衰弱风险。结果：分别有26.2%、31.0%、73.0%和46.4%的患者存在口咽性吞咽困难、营养不良、肌肉减少症及衰弱风险。晚期癌症患者在治疗前出现口咽性吞咽困难风险及高水平痛苦症状的比例显著更高。结论：本研究通过标准化的"快速简便"多维度筛查，明确了新诊断头颈癌患者在抗癌治疗前的风险特征。

原文链接：

Multi-Domain Screening: Identification of Patient’s Risk Profile Prior to Head-and-Neck Cancer Treatment