文章：

感兴趣区域大小对剪切波弹性成像鉴别甲状腺结节诊断性能的影响

Impact of Region-of-Interest Size on the Diagnostic Performance of Shear Wave Elastography in Differentiating Thyroid Nodules

原文发布日期：30 October 2023

DOI: 10.3390/cancers15215214

类型: Article

开放获取: 是

英文摘要：

This study investigated the impact of different region-of-interest (ROI) sizes (Max, 1 mm, and 2 mm) on shear wave elastography (SWE) in differentiating between malignant and benign thyroid nodules. The study cohort comprised 129 thyroid nodules (50 malignant, 79 benign) and 78 normal subjects. Diagnostic efficacy was assessed through pairwise comparisons of area under the curve (AUC) values in receiver operating characteristic analysis by using DeLong’s test. Our results indicated significant differences in all SWE elasticity metrics between the groups, with malignant nodules exhibiting higher values than benign nodules (p< 0.05). Smaller ROIs (1 and 2 mm) were found to outperform the max ROI in terms of diagnostic accuracy, particularly for theEmaxandEminelasticity metrics.Emax(1mm)had the highest diagnostic accuracy, with an AUC of 0.883, sensitivity of 74.0%, and specificity of 86.1%. This study underscores the significant influence of ROI size selection on the diagnostic performance of SWE, offering valuable insights for future research and clinical applications in thyroid nodule assessment.

摘要翻译： 

本研究探讨了不同感兴趣区域（ROI）尺寸（最大、1毫米及2毫米）对剪切波弹性成像（SWE）在鉴别甲状腺良恶性结节中的影响。研究队列包括129个甲状腺结节（50个恶性，79个良性）及78名正常受试者。通过DeLong检验对受试者工作特征曲线下面积（AUC）值进行两两比较，评估诊断效能。结果显示，各组间所有SWE弹性指标均存在显著差异，恶性结节的测量值高于良性结节（p<0.05）。在诊断准确性方面，较小ROI（1毫米和2毫米）优于最大ROI，尤其在最大弹性模量（Emax）和最小弹性模量（Emin）指标上表现突出。其中1毫米ROI的Emax值诊断效能最高，AUC达0.883，敏感性为74.0%，特异性为86.1%。本研究证实ROI尺寸选择对SWE诊断性能具有显著影响，为未来甲状腺结节评估的研究与临床应用提供了重要参考。

原文链接：

Impact of Region-of-Interest Size on the Diagnostic Performance of Shear Wave Elastography in Differentiating Thyroid Nodules