文章：

靶向肝转移以增强MS稳定型结直肠癌免疫治疗效果——文献综述

Targeting Liver Metastases to Potentiate Immunotherapy in MS-Stable Colorectal Cancer—A Review of the Literature

原文发布日期：30 October 2023

DOI: 10.3390/cancers15215210

类型: Article

开放获取: 是

英文摘要：

Immunotherapy has revolutionized the treatment of several cancers, including melanoma and lung cancer. However, for colorectal cancer, it is ineffective for 95% of patients with microsatellite-stable disease. Recent evidence suggests that the liver’s immune microenvironment plays a pivotal role in limiting the effectiveness of immunotherapy. There is also evidence to show that targeting liver metastases with locoregional therapies, such as surgery or irradiation, could potentiate immunotherapy for these patients. This review presents evidence from preclinical studies regarding the underlying mechanisms and from clinical studies that support this approach. Furthermore, we outline potential directions for future clinical trials. This innovative strategy could potentially establish immunotherapy as an effective treatment for MS-stable colorectal cancer patients, which are currently considered resistant.

摘要翻译： 

免疫疗法已彻底改变了包括黑色素瘤和肺癌在内的多种癌症的治疗方式。然而，对于结直肠癌患者而言，95%的微卫星稳定型患者对免疫治疗缺乏响应。最新研究表明，肝脏免疫微环境在限制免疫疗法疗效方面起着关键作用。同时有证据显示，通过手术或放疗等局部治疗手段针对肝转移灶进行干预，可能增强这类患者对免疫治疗的反应。本综述整合了临床前研究中关于潜在作用机制的证据，以及支持该治疗策略的临床研究数据。此外，我们提出了未来临床试验可能的发展方向。这一创新策略有望使免疫疗法成为当前被认为具有耐药性的微卫星稳定型结直肠癌患者的有效治疗手段。

原文链接：

Targeting Liver Metastases to Potentiate Immunotherapy in MS-Stable Colorectal Cancer—A Review of the Literature