Drug resistance remains a significant challenge in the treatment of colorectal cancer (CRC). In recent years, the emerging field of ferroptosis, a unique form of regulated cell death characterized by iron-dependent lipid peroxidation, has offered new insights and potential therapeutic strategies for overcoming drug resistance in CRC. This review examines the role of ferroptosis in CRC and its impact on drug resistance. It highlights the distinctive features and advantages of ferroptosis compared to other cell death pathways, such as apoptosis and necrosis. Furthermore, the review discusses current research advances in the field, including novel treatment approaches that target ferroptosis. These approaches involve the use of ferroptosis inducers, interventions in iron metabolism and lipid peroxidation, and combination therapies to enhance the efficacy of ferroptosis. The review also explores the potential of immunotherapy in modulating ferroptosis as a therapeutic strategy. Additionally, it evaluates the strengths and limitations of targeting ferroptosis, such as its selectivity, low side effects, and potential to overcome resistance, as well as challenges related to treatment specificity and drug development. Looking to the future, this review discusses the prospects of ferroptosis-based therapies in CRC, emphasizing the importance of further research to elucidate the interaction between ferroptosis and drug resistance. It proposes future directions for more effective treatment strategies, including the development of new therapeutic approaches, combination therapies, and integration with emerging fields such as precision medicine. In conclusion, harnessing ferroptosis represents a promising avenue for overcoming drug resistance in CRC. Continued research efforts in this field are crucial for optimizing therapeutic outcomes and providing hope for CRC patients.
耐药性仍是结直肠癌治疗中的重大挑战。近年来，铁死亡这一新兴领域——一种以铁依赖性脂质过氧化为特征的调节性细胞死亡形式——为克服结直肠癌耐药性提供了新的见解和潜在治疗策略。本文综述了铁死亡在结直肠癌中的作用及其对耐药性的影响，重点阐述了铁死亡相较于凋亡、坏死等其他细胞死亡途径的独特特征与优势。同时，文章系统梳理了该领域的最新研究进展，包括靶向铁死亡的新型治疗策略，如铁死亡诱导剂的应用、铁代谢与脂质过氧化的干预以及联合疗法增强铁死亡效应等。此外，本文探讨了免疫疗法调控铁死亡作为治疗策略的潜力，并评估了靶向铁死亡治疗的优势与局限，包括其选择性高、副作用小及克服耐药性潜力等优势，以及在治疗特异性与药物开发方面面临的挑战。展望未来，本文讨论了基于铁死亡的治疗策略在结直肠癌中的应用前景，强调需进一步深入研究铁死亡与耐药性的相互作用机制，并提出未来开发更有效治疗策略的方向，包括创新疗法研发、联合治疗方案设计以及与精准医疗等新兴领域的融合。总之，利用铁死亡机制为克服结直肠癌耐药性开辟了前景广阔的新途径，该领域的持续深入研究对优化治疗效果、为结直肠癌患者带来新希望具有重要意义。
肿瘤(癌症)患者之家