The potential involvement of a sexually transmitted agent has been suggested to contribute to the high number of prostate cancers in the United States and worldwide. We investigated the relationship ofTrichomonas vaginalisseropositivity with prostate cancer risk in a nested case–control study within the Multiethnic Cohort in Hawaii and California using blood samples collected prior to cancer diagnoses. Incident cases of advanced prostate cancer (intermediate- to high-grade based on Gleason score ≥ 7 and/or disease spread outside the prostate) were matched to controls by age, ethnicity, and the date of blood collection.T. vaginalisserostatus was measured using an ELISA detecting IgG antibodies against a recombinantT. vaginalisα-actinin protein. Seropositivity toT. vaginaliswas observed in 35 of 470 (7.4%) cases and 26 of 470 (5.5%) controls (unadjusted OR = 1.47, 95% CI 0.82–2.64; adjusted OR = 1.31, 95% CI 0.67–2.53). The association was similarly not significant when cases were confined to extraprostatic tumors having regional or distant spread (n= 121) regardless of grade (unadjusted OR = 1.37, 95% CI 0.63–3.01; adjusted OR = 1.20, 95% CI 0.46–3.11). The association ofT. vaginaliswith prostate cancer risk did not vary by aspirin use. Our findings do not support a role forT. vaginalisin the etiology of advanced prostate cancer.
有研究提示性传播病原体的潜在参与可能与美国及全球范围内前列腺癌的高发病率相关。我们在夏威夷和加利福尼亚多民族队列研究中，采用癌症诊断前采集的血液样本，通过巢式病例对照设计探讨了阴道毛滴虫血清阳性与前列腺癌风险的关系。将新发晚期前列腺癌病例（根据格里森评分≥7分为中高级别和/或疾病扩散至前列腺外）与对照组按年龄、种族和采血日期进行匹配。采用ELISA法检测针对重组阴道毛滴虫α-辅肌动蛋白的IgG抗体以确定血清学状态。在470例病例中，35例（7.4%）呈阴道毛滴虫血清阳性；470例对照中，26例（5.5%）呈阳性（未校正OR=1.47，95%CI 0.82–2.64；校正后OR=1.31，95%CI 0.67–2.53）。当病例局限于具有区域或远处扩散的前列腺外肿瘤（n=121）时，无论分级如何，该关联同样不显著（未校正OR=1.37，95%CI 0.63–3.01；校正后OR=1.20，95%CI 0.46–3.11）。阴道毛滴虫与前列腺癌风险的关联不因阿司匹林使用情况而异。我们的研究结果不支持阴道毛滴虫在晚期前列腺癌病因学中的作用。
肿瘤(癌症)患者之家