Preoperative cardiopulmonary exercise testing (CPET) provides an objective assessment of functional capability. In other intra-abdominal surgical specialties, CPET outcomes are predictive of operative morbidity. However, in ovarian cancer surgery, its predictive value remains unknown. In this study, we evaluated the association between CPET performance and surgical morbidity in ovarian cancer patients. Secondly, we assessed the association between CPET performance and other surgical outcomes (i.e., hospital stay, readmission and residual disease). This was a retrospective cohort study of patients undergoing primary surgery for ovarian cancer between 2020 and 2023. CPET performance included peak oxygen uptake (VO2max), ventilatory efficiency (VE/VO2) and anaerobic threshold. Outcomes were operative morbidity and included intra- and postoperative complications (Clavien–Dindo), hospital stay, readmission within 30 days and residual disease. A total of 142 patients were included. A lower VO2peak and a higher VE/VCO2were both associated with the occurrence of postoperative complications, and a poorer anaerobic threshold was associated with more transfusions. VE/VCO2remained significantly associated after multivariate analysis (p= 0.035). None of the CPET outcomes were associated with length of stay, readmission or residual disease. In conclusion, VE/VCO2was significantly associated with an increased risk of all-cause postoperative complications in ovarian cancer patients undergoing primary surgery.
术前心肺运动试验（CPET）可对患者的功能状态进行客观评估。在其他腹部外科手术中，CPET结果已被证实对手术并发症具有预测价值。然而，在卵巢癌手术领域，其预测作用尚不明确。本研究旨在探讨卵巢癌患者CPET表现与手术并发症之间的关联，并进一步评估CPET表现与其他手术结局（如住院时长、再入院率及残留病灶）的关系。本研究采用回顾性队列设计，纳入2020年至2023年间接受初次手术的卵巢癌患者。CPET评估指标包括峰值摄氧量（VO2max）、通气效率（VE/VO2）及无氧阈。结局指标涵盖术中与术后并发症（采用Clavien–Dindo分级）、住院时长、30天内再入院率及残留病灶情况。共纳入142例患者。研究发现，较低的峰值摄氧量与较高的VE/VCO2均与术后并发症发生相关，而无氧阈水平较低则与输血需求增加相关。经多变量分析后，VE/VCO2仍保持显著相关性（p=0.035）。所有CPET指标均未显示与住院时长、再入院率或残留病灶存在关联。结论：在接受初次手术的卵巢癌患者中，VE/VCO2与全因术后并发症风险增加显著相关。
肿瘤(癌症)患者之家