文章：

热休克因子1抑制：一种具有精准肿瘤学前景的新型抗癌策略

Heat Shock Factor 1 Inhibition: A Novel Anti-Cancer Strategy with Promise for Precision Oncology

原文发布日期：27 October 2023

DOI: 10.3390/cancers15215167

类型: Article

开放获取: 是

英文摘要：

Heat shock factor 1 (HSF1) is a transcription factor crucial for regulating heat shock response (HSR), one of the significant cellular protective mechanisms. When cells are exposed to proteotoxic stress, HSF1 induces the expression of heat shock proteins (HSPs) to act as chaperones, correcting the protein-folding process and maintaining proteostasis. In addition to its role in HSR, HSF1 is overexpressed in multiple cancer cells, where its activation promotes malignancy and leads to poor prognosis. The mechanisms of HSF1-induced tumorigenesis are complex and involve diverse signaling pathways, dependent on cancer type. With its important roles in tumorigenesis and tumor progression, targeting HSF1 offers a novel cancer treatment strategy. In this article, we examine the basic function of HSF1 and its regulatory mechanisms, focus on the mechanisms involved in HSF1′s roles in different cancer types, and examine current HSF1 inhibitors as novel therapeutics to treat cancers.

摘要翻译： 

热休克因子1（HSF1）是调控热休克反应（HSR）的关键转录因子，而热休克反应是细胞重要的保护机制之一。当细胞遭受蛋白毒性应激时，HSF1会诱导热休克蛋白（HSPs）的表达，这些蛋白作为分子伴侣协助纠正蛋白质折叠过程，维持蛋白质稳态。除了在热休克反应中的作用外，HSF1在多种癌细胞中过度表达，其激活会促进恶性肿瘤的发展并导致不良预后。HSF1诱导肿瘤发生的机制复杂，涉及多种信号通路，且依赖于癌症类型。鉴于HSF1在肿瘤发生和发展中的重要作用，靶向HSF1为癌症治疗提供了新的策略。本文探讨了HSF1的基本功能及其调控机制，重点分析了HSF1在不同癌症类型中的作用机制，并审视了当前作为新型癌症治疗药物的HSF1抑制剂。

原文链接：

Heat Shock Factor 1 Inhibition: A Novel Anti-Cancer Strategy with Promise for Precision Oncology