文章：

去分化子宫内膜癌：一种罕见侵袭性肿瘤的临床、形态学及免疫组化特征

Dedifferentiated Endometrial Carcinoma: A Rare Aggressive Neoplasm-Clinical, Morphological and Immunohistochemical Features

原文发布日期：26 October 2023

DOI: 10.3390/cancers15215155

类型: Article

开放获取: 是

英文摘要：

Dedifferentiated endometrioid adenocarcinoma is characterised by the coexistence of an undifferentiated carcinoma and a low-grade endometrioid adenocarcinoma. The low-grade component in this subtype of endometrial carcinoma is Grade 1 or 2 according to the Federation of Gynaecology and Obstetrics (FIGO) grading system. The coexistence of low-grade endometrial carcinoma and solid undifferentiated carcinoma can cause diagnostic problems on histological examination. In fact, this combination can often be mistaken for a more common Grade 2 or Grade 3 endometrial carcinoma. Therefore, this subtype of uterine carcinoma can often go under-recognised. An accurate diagnosis of dedifferentiated endometrial carcinoma is mandatory because of its poorer prognosis compared to Grade 3 endometrial carcinoma, with a solid undifferentiated component that can amount to as much as 20% of the entire tumour. The aim of this review is to provide clinical, immunohistochemical, and molecular data to aid with making an accurate histological diagnosis and to establish whether there are any findings which could have an impact on the prognosis or therapeutic implications of this rare and aggressive uterine neoplasm.

摘要翻译： 

去分化子宫内膜样腺癌的特征在于未分化癌与低级别子宫内膜样腺癌共存。根据国际妇产科联盟分级系统，该亚型子宫内膜癌中的低级别成分为1级或2级。低级别子宫内膜癌与实性未分化癌共存可能给组织学检查带来诊断难题。实际上，这种组合常被误认为更常见的2级或3级子宫内膜癌。因此，这种子宫癌亚型常被低估识别。由于相比3级子宫内膜癌预后更差，且实性未分化成分可占整个肿瘤的20%，必须对去分化子宫内膜癌进行准确诊断。本综述旨在提供临床、免疫组织化学和分子数据，以协助做出准确的组织学诊断，并确定是否存在可能影响这种罕见且侵袭性子宫肿瘤的预后或治疗意义的发现。

原文链接：

Dedifferentiated Endometrial Carcinoma: A Rare Aggressive Neoplasm-Clinical, Morphological and Immunohistochemical Features