Background: Cancer cases are continuously increasing, while the prevalence rates of physical inactivity are also continuously increasing. Physical inactivity is a causative factor in non-communicable diseases, including cancer. However, the potential beneficial effects of exercise on cancer treatment have not received much attention so far. The aim of this study was to highlight the relationship between cancer and exercise on a molecular basis. Methods: Comprehensive and in-depth research was conducted in the most accurate scientific databases by using relevant and effective keywords. Results: The mechanisms by which exercise may reduce cancer risk and/or progression may include the metabolic profile of hormones, systemic inflammation reduction, insulin sensitivity increase, antioxidant capacity augmentation, the boost to the immune system, and the direct effect on the tumor. There is currently substantial evidence that the effect of exercise may predict a stronger association with cancer and could supplementarily be embedded in cancer clinical practice to improve disease progression and prognosis. Conclusion: The field of this study requires interconnecting the overall knowledge of exercise physiology with cancer biology and cancer clinical oncology to provide the basis for personalized targeting strategies that can be merged with training as a component of a holistic co-treatment approach to optimize cancer healthcare.
背景：癌症病例持续增加，而身体活动不足的患病率亦不断攀升。缺乏身体活动是包括癌症在内的非传染性疾病的致病因素。然而，运动对癌症治疗的潜在有益效应迄今尚未获得足够重视。本研究旨在从分子层面阐明癌症与运动之间的关联机制。 方法：通过使用相关有效关键词，在权威科学数据库中进行全面深入的文献检索。 方法：通过使用相关有效关键词，在权威科学数据库中进行全面深入的文献检索。 结果：运动可能降低癌症风险和/或延缓病程进展的机制包括：调节激素代谢谱、降低全身性炎症水平、提高胰岛素敏感性、增强抗氧化能力、激活免疫系统以及对肿瘤产生直接作用。现有充分证据表明，运动效应与癌症存在显著关联，可作为补充手段融入癌症临床实践，从而改善疾病进展与预后。 结论：该研究领域需要将运动生理学的整体认知与癌症生物学及临床肿瘤学相结合，为个性化靶向策略提供理论基础。这些策略可与训练方案整合，形成综合协同治疗方案的重要组成部分，从而优化癌症医疗体系。
Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms
肿瘤(癌症)患者之家