A cellular sialome is a physiologically active and dynamically changing component of the cell membrane. Sialylation plays a crucial role in tumor progression, and alterations in cellular sialylation patterns have been described as modulators of chemotherapy effectiveness. However, the precise mechanisms through which altered sialylation contributes to drug resistance in cancer are not yet fully understood. This review focuses on the intricate interplay between sialylation and cancer treatment. It presents the role of sialic acids in modulating cell–cell interactions, the extracellular matrix (ECM), and the immunosuppressive processes within the context of cancer. The issue of drug resistance is also discussed, and the mechanisms that involve transporters, the tumor microenvironment, and metabolism are analyzed. The review explores drugs and therapeutic approaches that may induce modifications in sialylation processes with a primary focus on their impact on sialyltransferases or sialidases. Despite advancements in cellular glycobiology and glycoengineering, an interdisciplinary effort is required to decipher and comprehend the biological characteristics and consequences of altered sialylation. Additionally, understanding the modulatory role of sialoglycans in drug sensitivity is crucial to applying this knowledge in clinical practice for the benefit of cancer patients.
细胞唾液酸组是细胞膜上具有生理活性且动态变化的组成部分。唾液酸化在肿瘤进展中起着关键作用，细胞唾液酸化模式的改变已被证实是化疗疗效的调节因素。然而，唾液酸化改变导致癌症耐药的确切机制尚未完全阐明。本综述聚焦于唾液酸化与癌症治疗之间复杂的相互作用，系统阐述了唾液酸在调节细胞间相互作用、细胞外基质以及肿瘤免疫抑制过程中的作用机制。同时探讨了耐药性问题，分析了涉及转运蛋白、肿瘤微环境及代谢调控的耐药机制。本文还探讨了可能诱导唾液酸化过程改变的药物及治疗策略，重点关注其对唾液酸转移酶或唾液酸酶的影响。尽管细胞糖生物学和糖工程学已取得进展，仍需跨学科协作来解析和理解唾液酸化改变的生物学特性及其影响。此外，明确唾液酸化聚糖在药物敏感性中的调节作用，对于将这一知识应用于临床实践以造福癌症患者至关重要。
肿瘤(癌症)患者之家