Background: The Naples prognostic score (NPS) is a scoring system that reflects a patient’s systemic inflammatory and nutritional status. This study aimed to evaluate whether postoperative NPS is effective in assessing the prognosis of stage II–III colorectal cancer (CRC) patients compared with preoperative NPS. Methods: Between 2005 and 2012, a total of 164 patients diagnosed with stage II–III CRC, who underwent curative resection followed by adjuvant chemotherapy, were divided into two groups: Group 0–1 (NPS = 0–2) and Group 2 (NPS = 3 or 4). Preoperative NPS was calculated based on the results before surgeries, and postoperative NPS was assessed using the results obtained before adjuvant chemotherapy. Results: The overall survival of Group 0–1 was higher than that of Group 2 in both pre- and postoperative NPS assessments. According to the ROC curve analysis, the Area Under the Curve (AUC) ratio for postoperative NPS was 0.64, compared with 0.57 for preoperative NPS, 0.52 for the preoperative neutrophil–lymphocyte ratio (p= 0.032), and 0.51 for the preoperative platelet–lymphocyte ratio (p= 0.027). Conclusions: Postoperative NPS is effective in predicting the prognosis of stage II–III CRC patients who underwent curative resection followed by adjuvant chemotherapy. The use of NPS could be beneficial in evaluating the prognosis of CRC patients after surgeries.
背景：那不勒斯预后评分（NPS）是一种反映患者全身炎症与营养状态的评分系统。本研究旨在评估与术前NPS相比，术后NPS是否能够有效评估II–III期结直肠癌（CRC）患者的预后。方法：在2005年至2012年间，共纳入164例诊断为II–III期CRC并接受根治性切除术后辅助化疗的患者，将其分为两组：0–1组（NPS = 0–2）和2组（NPS = 3或4）。术前NPS基于手术前的结果计算，术后NPS则根据辅助化疗前获得的结果进行评估。结果：在术前和术后NPS评估中，0–1组的总生存率均高于2组。根据ROC曲线分析，术后NPS的曲线下面积（AUC）为0.64，而术前NPS为0.57，术前中性粒细胞-淋巴细胞比率为0.52（p=0.032），术前血小板-淋巴细胞比率为0.51（p=0.027）。结论：术后NPS能有效预测接受根治性切除术后辅助化疗的II–III期CRC患者的预后。应用NPS可能有助于评估CRC患者术后的预后情况。
肿瘤(癌症)患者之家