文章：

揭示慢性淋巴细胞白血病中的骨组织微环境

Unraveling the Bone Tissue Microenvironment in Chronic Lymphocytic Leukemia

原文发布日期：19 October 2023

DOI: 10.3390/cancers15205058

类型: Article

开放获取: 是

英文摘要：

Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western countries. Although characterized by the progressive expansion and accumulation of leukemic B cells in peripheral blood, CLL cells develop in protective niches mainly located within lymph nodes and bone marrow. Multiple interactions between CLL and microenvironmental cells may favor the expansion of a B cell clone, further driving immune cells toward an immunosuppressive phenotype. Here, we summarize the current understanding of bone tissue alterations in CLL patients, further addressing and suggesting how the multiple interactions between CLL cells and osteoblasts/osteoclasts can be involved in these processes. Recent findings proposing the disruption of the endosteal niche by the expansion of a leukemic B cell clone appear to be a novel field of research to be deeply investigated and potentially relevant to provide new therapeutic approaches.

摘要翻译： 

慢性淋巴细胞白血病（CLL）是西方国家中最常见的白血病类型。尽管其特征为外周血中白血病B细胞的进行性扩增与积累，但CLL细胞主要在淋巴结和骨髓的保护性微环境中发育。CLL细胞与微环境细胞间的多重相互作用可能促进B细胞克隆的扩增，并进一步驱动免疫细胞向免疫抑制表型转化。本文综述了目前对CLL患者骨组织改变的认识，进一步探讨并阐释了CLL细胞与成骨细胞/破骨细胞之间的多重相互作用如何参与这些病理过程。近期研究提出，白血病B细胞克隆的扩增会破坏骨内膜微环境，这似乎是一个有待深入探索的新研究领域，并可能为开发新的治疗方法提供重要依据。

原文链接：

Unraveling the Bone Tissue Microenvironment in Chronic Lymphocytic Leukemia