文章：

PDZ与LIM结构域编码基因：其在癌症发展中的作用

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

原文发布日期：19 October 2023

DOI: 10.3390/cancers15205042

类型: Article

开放获取: 是

英文摘要：

PDZ-LIM family proteins (PDLIMs) are a kind of scaffolding proteins that contain PDZ and LIM interaction domains. As protein–protein interacting molecules, PDZ and LIM domains function as scaffolds to bind to a variety of proteins. The PDLIMs are composed of evolutionarily conserved proteins found throughout different species. They can participate in cell signal transduction by mediating the interaction of signal molecules. They are involved in many important physiological processes, such as cell differentiation, proliferation, migration, and the maintenance of cellular structural integrity. Studies have shown that dysregulation of the PDLIMs leads to tumor formation and development. In this paper, we review and integrate the current knowledge on PDLIMs. The structure and function of the PDZ and LIM structural domains and the role of the PDLIMs in tumor development are described.

摘要翻译： 

PDZ-LIM家族蛋白（PDLIMs）是一类含有PDZ和LIM相互作用结构域的支架蛋白。作为蛋白质间相互作用分子，PDZ和LIM结构域通过结合多种蛋白质发挥支架功能。PDLIMs由进化上保守的蛋白质组成，广泛存在于不同物种中。它们能够通过介导信号分子间的相互作用参与细胞信号转导，涉及细胞分化、增殖、迁移及细胞结构完整性维持等重要生理过程。研究表明，PDLIMs的失调会导致肿瘤的形成与发展。本文系统综述并整合了当前关于PDLIMs的研究进展，重点阐述了PDZ和LIM结构域的结构与功能，以及PDLIMs在肿瘤发生发展中的作用。

原文链接：

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development