Background: The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing over the years. Risk factors for local recurrence and metastasis have been widely studied in highly sun-exposed areas of the body but less data exist about less sun-exposed ones. The main objective of this study is to compare the risk of local recurrence and metastases in patients with cSCC in highly sun-exposed areas compared to cSCC in less sun-exposed areas. Material and methods: A retrospective observational study was carried out, including 558 patients with histopathologically confirmed cSCC at the Reina Sofía University Hospital (HURS), Córdoba, during the period from 1 January 2017 to 31 December 2020. Demographic, clinical and anatomopathological data were collected. Results: Local recurrence occurs more often in highly sun-exposed areas (15.8%) compared to less sun-exposed ones (7.4%) (p< 0.05). However, no differences in the rate of metastases in both groups were found. The presence of affected surgical margins and tumor thickness were identified as independent risk factors for cSCC in low sun-exposure areas. Conclusions: cSCC located in anatomical areas of high sun exposure presented a greater risk of developing local recurrence in our population, which could suggest that these tumors have worse prognosis than those that lie in areas that do not receive chronic sun exposure.
背景：皮肤鳞状细胞癌（cSCC）的发病率近年来持续上升。目前针对身体高度日光暴露区域cSCC的局部复发和转移风险因素已有广泛研究，但对低度日光暴露区域的相关数据仍较缺乏。本研究主要目的是比较高度日光暴露区域与低度日光暴露区域cSCC患者的局部复发和转移风险。 材料与方法：本研究为回顾性观察性研究，纳入2017年1月1日至2020年12月31日期间在科尔多瓦雷纳索非亚大学医院经组织病理学确诊的558例cSCC患者。收集人口统计学、临床及解剖病理学数据。 结果：高度日光暴露区域的局部复发率（15.8%）显著高于低度日光暴露区域（7.4%）（p<0.05）。但两组间转移率无统计学差异。手术切缘受累和肿瘤厚度被确定为低度日光暴露区域cSCC的独立危险因素。 结论：在本研究人群中，位于高度日光暴露解剖区域的cSCC具有更高的局部复发风险，这可能提示此类肿瘤相较于非长期日光暴露区域的肿瘤预后更差。
肿瘤(癌症)患者之家