Cyclin D1, a critical cyclin-dependent kinase (CDK) 4/6-dependent regulator of G1/S transition, has attracted much interest as a therapeutic target. The cyclin D1 expression in small intestinal adenocarcinomas (SIACs) has not yet been comprehensively studied, owing to the rarity of this tumor. We investigated the clinicopathological and prognostic significance of the cyclin D1 expression in 232 surgically resected primary SIACs through a multi-institutional study. A high expression of cyclin D1 (cyclin D1High) was detected in 145 SIAC cases (63%), which was significantly higher than that in normal small intestinal mucosa (11%). Cyclin D1Highwas more commonly found in SIACs with a lower T-category and disease stage andKRASmutation and predicted better patient survival. Multivariate analysis revealed that cyclin D1High, the absence of retroperitoneal seeding and lymphovascular invasion, and the lower N-category were identified as independent prognostic indicators for patients with SIACs. Specifically, cyclin D1Highaffected patient survival in the lower stage group (stages I and II). In conclusion, cyclin D1 was commonly overexpressed in SIACs, and cyclin D1Highacted as a favorable prognostic indicator in patients with SIACs. These findings in SIACs may, thus, be important to further comprehend the mechanism of cyclin D1 in carcinogenesis and to strategize appropriate patient therapies.
细胞周期蛋白D1是G1/S期转换的关键性周期蛋白依赖性激酶（CDK）4/6依赖性调节因子，作为治疗靶点备受关注。由于小肠腺癌（SIACs）较为罕见，其细胞周期蛋白D1的表达尚未得到全面研究。我们通过多机构研究，对232例手术切除的原发性SIACs中细胞周期蛋白D1表达的临床病理学及预后意义进行了探讨。在145例SIACs（63%）中检测到细胞周期蛋白D1高表达（cyclin D1High），显著高于正常小肠黏膜的表达水平（11%）。cyclin D1High更常见于T分期较低、疾病分期较低以及存在KRAS突变的SIACs，并预示着患者更好的生存率。多变量分析显示，cyclin D1High、无腹膜后播散和淋巴血管侵犯以及较低的N分期被确定为SIACs患者的独立预后指标。具体而言，cyclin D1High在较低分期组（I期和II期）中影响患者生存。总之，细胞周期蛋白D1在SIACs中普遍过表达，且cyclin D1High是SIACs患者良好的预后指标。因此，这些关于SIACs的发现可能对进一步理解细胞周期蛋白D1在致癌机制中的作用以及制定合适的患者治疗策略具有重要意义。
Prognostic Significance of Cyclin D1 Expression in Small Intestinal Adenocarcinoma
肿瘤(癌症)患者之家