Background:Liver cancer and notably hepatocellular carcinoma (HCC), results in significantly high mortality rates worldwide. Chronic hepatitis and fatty liver, recognized precursors, underscore the imperative need for effective preventive strategies. This study explores colchicine, traditionally acknowledged for its anti-inflammatory properties and investigates its potential in liver cancer prevention.Methods:Utilizing the iHi Data Platform of China Medical University Hospital, Taiwan, this study analyzed two decades of medical data, incorporating 10,353 patients each in the Colchicine and Non-Colchicine cohorts, to investigate the association between colchicine use and liver cancer risk.Results:The study identified that colchicine users exhibited a 19% reduction in liver cancer risk, with a multivariable-adjusted odds ratio of 0.81 after accounting for confounding variables. Additionally, the influence of gender and comorbidities like diabetes mellitus on liver cancer risk was identified, corroborating the existing literature. A notable finding was that the prolonged use of colchicine was associated with improved outcomes, indicating a potential dose–response relationship.Conclusions:This study proposes a potential new role for colchicine in liver cancer prevention, extending beyond its established anti-inflammatory applications. While the findings are promising, further research is essential to validate these results. This research may serve as a foundation for future studies, aiming to further explore colchicine’s role via clinical trials and in-depth investigations, potentially impacting preventive strategies for liver cancer.
背景：肝癌，特别是肝细胞癌（HCC），在全球范围内导致极高的死亡率。慢性肝炎和脂肪肝作为公认的癌前病变，凸显了制定有效预防策略的迫切需求。本研究探讨了秋水仙碱——一种传统上以其抗炎特性而闻名的药物——在预防肝癌方面的潜在作用。 方法：本研究利用台湾中国医药大学医院的iHi数据平台，分析了二十年的医疗数据，纳入秋水仙碱组与非秋水仙碱组各10,353名患者，以探究秋水仙碱使用与肝癌风险之间的关联。 结果：研究发现，秋水仙碱使用者的肝癌风险降低了19%，在调整混杂变量后，多变量调整后的比值比为0.81。此外，研究还确认了性别以及糖尿病等合并症对肝癌风险的影响，这与现有文献相符。一个值得注意的发现是，长期使用秋水仙碱与改善预后相关，表明可能存在剂量-反应关系。 结论：本研究提出了秋水仙碱在预防肝癌方面可能具有的新作用，这超越了其既定的抗炎应用。尽管研究结果前景可观，但仍需进一步研究以验证这些发现。本研究可为未来研究奠定基础，旨在通过临床试验和深入调查进一步探索秋水仙碱的作用，并可能对肝癌的预防策略产生影响。
Unlocking Colchicine’s Untapped Potential: A Paradigm Shift in Hepatocellular Carcinoma Prevention
肿瘤(癌症)患者之家