文章：

遗传风险与社会经济因素对甲状腺癌的交互作用：基于英国生物银行50万参与者的证据

Interaction between Genetic Risks and Socioeconomic Factors on Thyroid Cancer: Evidence from 0.5 Million UK Biobank Participants

原文发布日期：18 October 2023

DOI: 10.3390/cancers15205028

类型: Article

开放获取: 是

英文摘要：

Background: There is a research gap between genetic predisposition, socioeconomic factors, and their interactions on thyroid tumorigenesis. Methods: Individual and genetic data were obtained from UK Biobank. Logistic regression models were used to evaluate the association between genetic risk, socioeconomic factors, and thyroid cancer (TCa). A stratified analysis was conducted to estimate their joint effects. A two-sample Mendelian randomization (MR) analysis was further used to examine the potential causality. Results: A total of 502,394 participants were included in this study. Three index loci (rs4449583, rs7726159, and rs7725218) of telomerase reverse transcriptase (TERT) were found to be significantly related to incident TCa. Association analyses showed that high genetic risk, low household income, and high education level were independent risk factors, while unemployment and frequent social connection were suggestive risk factors for TCa. Interaction analyses showed that in participants with low genetic risk, low household income was significantly associated with TCa (odds ratio [OR] = 1.56, 95% confidence interval [CI]: 1.00–2.46). In participants with high genetic risk, those with a high education level (OR = 1.32, 95%CI: 1.06–1.65) and frequent social connection (OR = 1.36, 95%CI: 1.02–1.81) had a significantly increased risk of TCa. However, no causal relationship was observed in the MR analysis. Conclusion: Interactions exist between genetic risk, household income, education level, and social connection and thyroid cancer.

摘要翻译： 

背景：目前关于遗传易感性、社会经济因素及其交互作用对甲状腺肿瘤发生的影响存在研究空白。方法：本研究从英国生物样本库获取个体与遗传数据。采用逻辑回归模型评估遗传风险、社会经济因素与甲状腺癌之间的关联性，并通过分层分析评估其联合效应。进一步采用双样本孟德尔随机化分析检验潜在因果关系。结果：本研究共纳入502,394名参与者。发现端粒酶逆转录酶（TERT）的三个索引位点（rs4449583、rs7726159和rs7725218）与甲状腺癌发病显著相关。关联分析显示，高遗传风险、低家庭收入和高教育水平是甲状腺癌的独立危险因素，而失业状态和频繁社交联系则提示为潜在危险因素。交互作用分析表明：在低遗传风险人群中，低家庭收入与甲状腺癌显著相关（比值比[OR]=1.56，95%置信区间[CI]:1.00–2.46）；在高遗传风险人群中，高教育水平（OR=1.32，95%CI:1.06–1.65）和频繁社交联系（OR=1.36，95%CI:1.02–1.81）显著增加甲状腺癌风险。然而，孟德尔随机化分析未观察到因果关系。结论：遗传风险、家庭收入、教育水平和社交联系与甲状腺癌存在交互作用。

原文链接：

Interaction between Genetic Risks and Socioeconomic Factors on Thyroid Cancer: Evidence from 0.5 Million UK Biobank Participants