文章：

碳离子放射治疗：基于证据的回顾及颅底脊索瘤与软骨肉瘤临床疗效总结建议

Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas

原文发布日期：17 October 2023

DOI: 10.3390/cancers15205021

类型: Article

开放获取: 是

英文摘要：

Skull-base chordoma and chondrosarcoma are rare radioresistant tumors treated with surgical resection and/or radiotherapy. Because of the established dosimetric and biological benefits of heavy particle therapy, we performed a systematic and evidence-based review of the clinical outcomes of patients with skull-base chordoma and chondrosarcoma treated with carbon ion radiotherapy (CIRT). A literature review was performed using a MEDLINE search of all articles to date. We identified 227 studies as appropriate for review, and 24 were ultimately included. The published data illustrate that CIRT provides benchmark disease control outcomes for skull-base chordoma and chondrosarcoma, respectively, with acceptable toxicity. CIRT is an advanced treatment technique that may provide not only dosimetric benefits over conventional photon therapy but also biologic intensification to overcome mechanisms of radioresistance. Ongoing research is needed to define the magnitude of benefit, patient selection, and cost-effectiveness of CIRT compared to other forms of radiotherapy.

摘要翻译： 

颅底脊索瘤和软骨肉瘤是罕见的放射抵抗性肿瘤，通常采用手术切除和/或放射治疗。鉴于重粒子治疗在剂量学和生物学方面已证实的优势，我们对接受碳离子放射治疗（CIRT）的颅底脊索瘤和软骨肉瘤患者的临床结果进行了系统性循证回顾。通过MEDLINE数据库检索截至当前所有相关文献，共筛选出227项符合条件的研究，最终纳入24项。已发表数据表明，CIRT分别为颅底脊索瘤和软骨肉瘤提供了标杆性的疾病控制效果，且毒性反应可接受。作为一种先进治疗技术，CIRT不仅较传统光子治疗具有剂量学优势，还能通过生物强化作用克服放射抵抗机制。未来需进一步开展研究，以明确CIRT相较于其他放射治疗形式的获益程度、患者选择标准及成本效益。

原文链接：

Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas