Stereotactic body radiation therapy (SBRT) is a precise and conformal radiation therapy (RT) that aims to deliver a high dose of radiation to the tumor whilst sparing surrounding normal tissue, making it an attractive option for head and neck cancer (HNC) patients who are not suitable for the traditional long course of RT with comprehensive RT target volume. Definitive SBRT for HNC has been investigated in different settings, including early stage glottis cancer, and as an alternative to brachytherapy boost after external beam RT. It is also used as a primary treatment option for elderly or medically unfit patients. More recently, an SBRT combination with immunotherapy in the neoadjuvant setting for HNC showed promising results. Salvage or adjuvant SBRT for HNC can be used in appropriately selected cases. Future studies are warranted to determine the optimum dose and fractionation schedules in any of these indications.
立体定向放射治疗（SBRT）是一种精确适形的放射治疗技术，旨在向肿瘤输送高剂量辐射的同时保护周围正常组织。对于不适合接受传统长疗程大范围放疗的头颈癌患者而言，该技术具有显著优势。根治性SBRT在头颈癌治疗中的应用已在不同场景中得到研究，包括早期声门癌治疗，以及作为外照射放疗后近距离放疗推量的替代方案。该技术还可作为老年或身体状况不佳患者的主要治疗选择。近期研究显示，新辅助治疗中SBRT联合免疫疗法治疗头颈癌展现出良好前景。对于经过严格筛选的病例，可采用挽救性或辅助性SBRT治疗。未来仍需进一步研究以确定各类适应症的最佳剂量和分次方案。
肿瘤(癌症)患者之家