Background: Evidence for an association between atopic dermatitis (AD) and cancer is still insufficient. In particular, the association between the risk of renal malignancy and the severity of AD has not been thoroughly investigated. Objective: To investigate the risk of renal malignancy and determine the association between AD severity and cancer risk using data from the Korean National Health Insurance Service (KNHIS) database. Methods: We performed a population-based cohort study using the National Health Claims database from the NHIS in Korea. Results: We found a statistically significant association between AD and overall malignancy (for mild AD, hazard ratio (HR): 1.061, 95% confidence interval (CI): 1.006–1.118; for moderate to severe AD, HR: 1.061, 95% CI: 1.014–1.11) compared with the no AD group. The moderate to severe AD group showed a significantly increased risk for renal malignancy (adjusted HR: 1.533, 95% CI: 1.209–1.944) compared with the no AD group. Limitations: Patient inclusion is solely based on diagnostic codes. We had no data about drug use, genetic factors, or other medical history that could affect the cancer risk. Conclusion: In our large population-based cohort study, moderate to severe AD was associated with increased risk of renal malignancy. Regular check-ups for renal malignancy are recommended in this population.
背景：特应性皮炎（AD）与癌症之间的关联性证据尚不充分。特别是AD严重程度与肾恶性肿瘤风险之间的关联尚未得到深入研究。目的：利用韩国国民健康保险公团（KNHIS）数据库数据，探究肾恶性肿瘤风险，并确定AD严重程度与癌症风险之间的关联。方法：我们基于韩国国民健康保险公团的国家健康理赔数据库开展了一项人群队列研究。结果：与无AD组相比，我们发现AD与总体恶性肿瘤风险存在统计学显著关联（轻度AD的风险比（HR）：1.061，95%置信区间（CI）：1.006–1.118；中重度AD的HR：1.061，95% CI：1.014–1.11）。中重度AD组与无AD组相比，肾恶性肿瘤风险显著增加（校正后HR：1.533，95% CI：1.209–1.944）。局限性：患者纳入仅基于诊断代码。我们缺乏可能影响癌症风险的药物使用、遗传因素或其他病史数据。结论：在我们这项大规模人群队列研究中，中重度AD与肾恶性肿瘤风险增加相关。建议对该人群进行定期肾恶性肿瘤筛查。
Increased Risk of Renal Malignancy in Patients with Moderate to Severe Atopic Dermatitis
肿瘤(癌症)患者之家