文章：

人巨细胞病毒感染前列腺上皮细胞产生的多倍体巨型癌细胞

Polyploid Giant Cancer Cells Generated from Human Cytomegalovirus-Infected Prostate Epithelial Cells

原文发布日期：15 October 2023

DOI: 10.3390/cancers15204994

类型: Article

开放获取: 是

英文摘要：

Background: Prostate cancer is the most commonly diagnosed malignancy and the sixth leading cause of cancer death in men worldwide. Chromosomal instability (CIN) and polyploid giant cancer cells (PGCCs) have been considered predominant hallmarks of cancer. Recent clinical studies have proven the association of CIN, aneuploidy, and PGCCs with poor prognosis of prostate cancer (PCa). Evidence of HCMV transforming potential might indicate that HCMV may be involved in PCa. Methods: Herein, we underline the role of the high-risk HCMV-DB and -BL clinical strains in transforming prostate epithelial cells and assess the molecular and cellular oncogenic processes associated with PCa. Results: Oncogenesis parallels a sustained growth of “CMV-Transformed Prostate epithelial cells” or CTP cells that highly express Myc and EZH2, forming soft agar colonies and displaying stemness as well as mesenchymal features, hence promoting EMT as well as PGCCs and a spheroid appearance. Conclusions: HCMV-induced Myc and EZH2 upregulation coupled with stemness and EMT traits in IE1-expressing CTP might highlight the potential role of HCMV in PCa development and encourage the use of anti-EZH2 and anti-HCMV in PCa treatment.

摘要翻译： 

背景：前列腺癌是全球男性中最常被诊断出的恶性肿瘤，也是导致癌症死亡的第六大原因。染色体不稳定性（CIN）和多倍体巨癌细胞（PGCCs）被认为是癌症的主要特征。最近的临床研究证实，CIN、非整倍体和PGCCs与前列腺癌（PCa）的不良预后相关。人类巨细胞病毒（HCMV）转化潜能的证据可能表明HCMV参与了PCa的发生。方法：本文重点探讨了高风险HCMV-DB和-BL临床毒株在前列腺上皮细胞转化中的作用，并评估了与PCa相关的分子和细胞致癌过程。结果：致癌过程伴随着“CMV转化前列腺上皮细胞”（CTP细胞）的持续生长，这些细胞高表达Myc和EZH2，能够形成软琼脂集落，并表现出干细胞特性及间质特征，从而促进上皮-间质转化（EMT）、PGCCs形成以及球状外观。结论：HCMV诱导的Myc和EZH2上调，结合表达IE1的CTP细胞中的干细胞特性和EMT特征，可能突显了HCMV在PCa发展中的潜在作用，并支持在前列腺癌治疗中使用抗EZH2和抗HCMV药物。

原文链接：

Polyploid Giant Cancer Cells Generated from Human Cytomegalovirus-Infected Prostate Epithelial Cells