While previous research has primarily focused on the impact ofH. pyloriand Epstein-Barr virus (EBV), emerging evidence suggests that other microbial influences, including viral and fungal infections, may also contribute to gastric cancer (GC) development. The intricate interactions between these microbes and the host’s immune response provide a more comprehensive understanding of gastric cancer pathogenesis, diagnosis, and treatment. The review highlights the roles of established players such asH. pyloriand EBV and the potential impacts of gut bacteria, mainlyLactobacillus,Streptococcus, hepatitis B virus, hepatitis C virus, and fungi such asCandida albicans. Advanced sequencing technologies offer unprecedented insights into the complexities of the gastric microbiome, from microbial diversity to potential diagnostic applications. Furthermore, the review highlights the potential for advanced GC diagnosis and therapies through a better understanding of the gut microbiome.
既往研究主要聚焦于幽门螺杆菌（H. pylori）与EB病毒（EBV）的影响，而新近证据表明其他微生物因素——包括病毒与真菌感染——也可能参与胃癌（GC）的发生发展。这些微生物与宿主免疫反应之间复杂的相互作用，为更全面理解胃癌的发病机制、诊断及治疗提供了新视角。本综述系统阐述了幽门螺杆菌与EB病毒等已知病原体的作用，同时探讨了肠道细菌（主要为乳杆菌属、链球菌属）、乙型肝炎病毒、丙型肝炎病毒以及白色念珠菌等真菌的潜在影响。先进的测序技术为解析胃微生物组的复杂性——从微生物多样性到潜在诊断应用——提供了前所未有的见解。此外，通过深入理解肠道微生物组，本综述还展望了其在胃癌精准诊断与治疗中的潜在应用前景。
肿瘤(癌症)患者之家