The microbiome, once considered peripheral, is emerging as a relevant player in the intricate web of factors contributing to cancer development and progression. These often overlooked microorganisms, in the context of urological malignancies, have been investigated primarily focusing on the gut microbiome, while exploration of urogenital microorganisms remains limited. Considering this, our systematic review delves into the complex role of these understudied actors in various neoplastic conditions, including prostate, bladder, kidney, penile, and testicular cancers. Our analysis found a total of 37 studies (prostate cancer 12, bladder cancer 20, kidney cancer 4, penile/testicular cancer 1), revealing distinct associations specific to each condition and hinting at potential therapeutic avenues and future biomarker discoveries. It becomes evident that further research is imperative to unravel the complexities of this domain and provide a more comprehensive understanding.
微生物组曾被视为次要因素，现正逐渐成为影响癌症发生与发展的复杂网络中的重要参与者。在泌尿系统恶性肿瘤的研究中，这些常被忽视的微生物主要聚焦于肠道微生物组，而对泌尿生殖道微生物的探索仍较为有限。鉴于此，本系统性综述深入探讨了这些尚未被充分研究的微生物在前列腺癌、膀胱癌、肾癌、阴茎癌及睾丸癌等多种肿瘤疾病中的复杂作用。通过分析总计37项研究（前列腺癌12项、膀胱癌20项、肾癌4项、阴茎/睾丸癌1项），我们发现不同疾病存在特定的微生物关联，并提示了潜在的治疗途径及未来生物标志物的发现方向。显然，这一领域仍需进一步深入研究以揭示其复杂性，从而提供更全面的认知。
The Influence of the Microbiome on Urological Malignancies: A Systematic Review
肿瘤(癌症)患者之家