文章：

靶向肝细胞癌中异质性肿瘤相关巨噬细胞

Targeting the Heterogeneous Tumour-Associated Macrophages in Hepatocellular Carcinoma

原文发布日期：13 October 2023

DOI: 10.3390/cancers15204977

类型: Article

开放获取: 是

英文摘要：

Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer that comprises a complex tumour microenvironment (TME). Tumour-associated macrophages (TAMs) are one of the most abundant immune cells present in the TME, and play a key role both in the development and in the progression of HCC. Thus, TAM-based immunotherapy has been presented as a promising strategy to complement the currently available therapies for HCC treatment. Among the novel approaches focusing on TAMs, reprogramming their functional state has emerged as a promising option for targeting TAMs as an immunotherapy in combination with the currently available treatment options. Nevertheless, a further understanding of the immunobiology of TAMs is still required. This review synthesizes current insights into the heterogeneous nature of TAMs in HCC and describes the mechanisms behind their pro-tumoural polarization focusing the attention on their interaction with HCC cells. Furthermore, this review underscores the potential involvement of TAMs’ reprogramming in HCC therapy and highlights the urgency of advancing our understanding of these cells within the dynamic landscape of HCC.

摘要翻译： 

肝细胞癌（HCC）是一种普遍且侵袭性强的癌症，其肿瘤微环境（TME）构成复杂。肿瘤相关巨噬细胞（TAMs）是TME中最丰富的免疫细胞之一，在HCC的发生和发展过程中均发挥关键作用。因此，基于TAM的免疫疗法已成为补充现有HCC治疗手段的一种有前景的策略。在针对TAM的新型疗法中，重编程其功能状态已成为一种有潜力的方向，可将TAM靶向免疫疗法与现有治疗方案相结合。然而，对TAM免疫生物学的深入理解仍有待加强。本综述整合了当前对HCC中TAM异质性的认识，阐述了其促肿瘤极化的机制，重点关注其与HCC细胞的相互作用。此外，本文强调了TAM重编程在HCC治疗中的潜在应用价值，并指出在HCC动态演变背景下深化对这些细胞认知的紧迫性。

原文链接：

Targeting the Heterogeneous Tumour-Associated Macrophages in Hepatocellular Carcinoma