There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC.
关于宫颈癌中肿瘤浸润免疫细胞（TIICs）的研究众多，但其预后价值与组织病理学亚型的相关性尚未得到探讨。因此，本研究旨在量化238例散发性宫颈癌样本中的TIICs，并探究其与宫颈癌亚型及患者生存期的相关性。与宫颈腺癌（47例样本）相比，宫颈鳞状细胞癌亚组（191例样本）中的TIICs水平显著升高。在宫颈鳞状细胞癌中，TIICs浸润与年龄、FIGO分期以及组蛋白修饰H3K4me3呈负相关。此外，在宫颈腺癌中，TIICs浸润与p16及糖皮质激素受体呈正相关，而与MDM2蛋白及H3K4me3呈负相关。值得注意的是，在宫颈鳞状细胞癌患者中，免疫浸润是无病生存期的独立正向预后因素，TIICs浸润程度最高的患者表现出更优的无病生存期。综上所述，本研究系统阐述了宫颈鳞状细胞癌与宫颈腺癌患者中TIICs水平与预后关系的差异性。
Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma
肿瘤(癌症)患者之家