Recent studies suggest that PEBP1 (also known as RKIP) and YY1, despite having distinct molecular functions, may interact and mutually influence each other’s activity. They exhibit reciprocal control over each other’s expression through regulatory loops, prompting the hypothesis that their interplay could be pivotal in cancer advancement and resistance to drugs. To delve into this interplay’s functional characteristics, we conducted a comprehensive analysis using bioinformatics tools across a range of cancers. Our results confirm the association between elevated YY1 mRNA levels and varying survival outcomes in diverse tumors. Furthermore, we observed differing degrees of inhibitory or activating effects of these two genes in apoptosis, cell cycle, DNA damage, and other cancer pathways, along with correlations between their mRNA expression and immune infiltration. Additionally, YY1/PEBP1 expression and methylation displayed connections with genomic alterations across different cancer types. Notably, we uncovered links between the two genes and different indicators of immunosuppression, such as immune checkpoint blockade response and T-cell dysfunction/exclusion levels, across different patient groups. Overall, our findings underscore the significant role of the interplay between YY1 and PEBP1 in cancer progression, influencing genomic changes, tumor immunity, or the tumor microenvironment. Additionally, these two gene products appear to impact the sensitivity of anticancer drugs, opening new avenues for cancer therapy.
近期研究表明，PEBP1（亦称RKIP）与YY1虽具有不同的分子功能，但可能存在相互作用并相互影响彼此活性。二者通过调控环路实现对彼此表达的相互制约，这提示它们的相互作用可能在癌症进展及耐药性中发挥关键作用。为深入探究该相互作用的功能特性，我们运用生物信息学工具对多种癌症进行了综合分析。研究结果证实，YY1 mRNA水平升高与不同肿瘤的生存结局变化存在关联。此外，我们观察到这两个基因在细胞凋亡、细胞周期、DNA损伤及其他癌症通路中呈现不同程度的抑制或激活效应，同时其mRNA表达与免疫浸润存在相关性。值得注意的是，YY1/PEBP1的表达及甲基化状态在不同癌症类型中均显示出与基因组改变的相关性。特别值得关注的是，我们在不同患者群体中发现这两个基因与免疫抑制的多种指标存在关联，包括免疫检查点阻断反应及T细胞功能障碍/排斥水平等。总体而言，我们的研究结果揭示了YY1与PEBP1相互作用在癌症进展中的重要作用，这种作用通过影响基因组改变、肿瘤免疫或肿瘤微环境来实现。此外，这两种基因产物似乎能够影响抗癌药物的敏感性，这为癌症治疗开辟了新的途径。
Cross-Talks between RKIP and YY1 through a Multilevel Bioinformatics Pan-Cancer Analysis
肿瘤(癌症)患者之家