文章：

吲哚菁绿荧光淋巴结示踪技术在腹腔镜右半结肠切除术中的临床有效性：一项前瞻性病例对照研究

Clinical Effectiveness of Fluorescence Lymph Node Mapping Using ICG for Laparoscopic Right Hemicolectomy: A Prospective Case–Control Study

原文发布日期：10 October 2023

DOI: 10.3390/cancers15204927

类型: Article

开放获取: 是

英文摘要：

Background: The distinction between D3 lymph nodes and actual lymphatic pathways in primary tumors can be difficult during surgery, making it challenging to confirm the completeness of D3 lymph node dissection. Fluorescence lymph node mapping (FLNM) is a promising method for lymph node visualization. Purpose: This study aimed to assess whether FLNM enhances the effectiveness of D3 lymph node dissection in patients with right-sided colon cancer. Methods: Endoscopic submucosal indocyanine green injection were performed on the distal margin of the colon cancer. In an FLNM group, the lymphatic drainage pathway and distribution of D3 lymph nodes were explored. Pathological evaluations were conducted for the fluorescent D3 and non-fluorescent D3 lymph nodes. Results: The FLNM group showed a significantly higher number of harvested lymph nodes in the D3 area. In stage III patients, the proportion of D3 lymph node metastasis was significantly higher in the FLNM group. The harvested D3 lymph node count showed a proportional correlation with a metastatic lymph node count of up to 15. Conclusion: FLNM could be considered a promising new strategy to potentially increase harvested D3 lymph node counts in colon cancer surgery.

摘要翻译： 

背景：在手术中，原发性肿瘤的D3淋巴结与真实淋巴通路之间的区分可能较为困难，这使得确认D3淋巴结清扫的完整性具有挑战性。荧光淋巴结显影（FLNM）是一种有前景的淋巴结可视化方法。目的：本研究旨在评估FLNM是否能提高右侧结肠癌患者D3淋巴结清扫的效果。方法：在结肠癌远端边缘进行内镜黏膜下吲哚菁绿注射。在FLNM组中，探索了淋巴引流通路和D3淋巴结的分布。对荧光D3和非荧光D3淋巴结进行了病理学评估。结果：FLNM组在D3区域获取的淋巴结数量显著更高。在III期患者中，FLNM组的D3淋巴结转移比例显著更高。获取的D3淋巴结数量与转移淋巴结数量呈正相关，最多可达15个。结论：FLNM可被视为一种有前景的新策略，可能增加结肠癌手术中D3淋巴结的获取数量。

原文链接：

Clinical Effectiveness of Fluorescence Lymph Node Mapping Using ICG for Laparoscopic Right Hemicolectomy: A Prospective Case–Control Study