文章：

神经系统发育调节因子Neuropilin-1作为脑癌潜在预后标志物与治疗靶点

The Nervous System Development Regulator Neuropilin-1 as a Potential Prognostic Marker and Therapeutic Target in Brain Cancer

原文发布日期：10 October 2023

DOI: 10.3390/cancers15204922

类型: Article

开放获取: 是

英文摘要：

Neuropilins are transmembrane glycoproteins that regulate developmental processes in the nervous system and other tissues. Overexpression of neuropilin-1 (NRP1) occurs in many solid tumor types and, in several instances, may predict patient outcome in terms of overall survival. Experimental inhibition of NRP1 activity can display antitumor effects in different cancer models. Here, we review NRP1 expression and function in adult and pediatric brain cancers, particularly glioblastomas (GBMs) and medulloblastomas, and present analyses of NRP1 transcript levels and their association with patient survival in GBMs. The case of NRP1 highlights the potential of regulators of neurodevelopment as biomarkers and therapeutic targets in brain cancer.

摘要翻译： 

神经纤毛蛋白是跨膜糖蛋白，在神经系统及其他组织的发育过程中发挥调控作用。神经纤毛蛋白-1（NRP1）在多种实体肿瘤中呈现过表达现象，且在若干病例中其表达水平可作为预测患者总生存期的指标。实验性抑制NRP1活性在不同癌症模型中均显示出抗肿瘤效应。本文系统综述了NRP1在成人与儿童脑肿瘤（特别是胶质母细胞瘤和髓母细胞瘤）中的表达模式与功能机制，并通过分析胶质母细胞瘤中NRP1转录水平及其与患者生存期的关联性，论证了神经发育调控因子作为脑肿瘤生物标志物和治疗靶点的潜在价值。NRP1的研究案例凸显了神经发育调控因子在脑肿瘤诊疗领域的重要转化潜力。

原文链接：

The Nervous System Development Regulator Neuropilin-1 as a Potential Prognostic Marker and Therapeutic Target in Brain Cancer