Brain cancer is known as one of the deadliest cancers globally. One of the causative factors is the imbalance between oxidative and antioxidant activities in the body, which is referred to as oxidative stress (OS). As part of regular metabolism, oxygen is reduced by electrons, resulting in the creation of numerous reactive oxygen species (ROS). Inflammation is intricately associated with the generation of OS, leading to the increased production and accumulation of reactive oxygen and nitrogen species (RONS). Glioma stands out as one of the most common malignant tumors affecting the central nervous system (CNS), characterized by changes in the redox balance. Brain cancer cells exhibit inherent resistance to most conventional treatments, primarily due to the distinctive tumor microenvironment. Oxidative stress (OS) plays a crucial role in the development of various brain-related malignancies, such as glioblastoma multiforme (GBM) and medulloblastoma, where OS significantly disrupts the normal homeostasis of the brain. In this review, we provide in-depth descriptions of prospective targets and therapeutics, along with an assessment of OS and its impact on brain cancer metabolism. We also discuss targeted therapies.
脑癌是全球公认最致命的癌症之一。其致病因素之一是体内氧化与抗氧化活动失衡，即氧化应激。作为常规代谢的一部分，氧气被电子还原，产生大量活性氧。炎症与氧化应激的产生密切相关，导致活性氧和活性氮的生成增加和积累。胶质瘤是中枢神经系统最常见的恶性肿瘤之一，其特征是氧化还原平衡的改变。脑癌细胞对大多数常规治疗具有内在抗性，这主要归因于独特的肿瘤微环境。氧化应激在各种脑部恶性肿瘤（如多形性胶质母细胞瘤和髓母细胞瘤）的发展中起着关键作用，它显著破坏了大脑的正常稳态。本综述深入探讨了潜在的治疗靶点和治疗方法，评估了氧化应激及其对脑癌代谢的影响，并讨论了靶向治疗策略。
Role of Oxidative Stress in Metabolic Reprogramming of Brain Cancer
肿瘤(癌症)患者之家