The association between Hashimoto’s thyroiditis (HT) and pediatric thyroid cancer is controversial. Most studies examining this connection have been based on adults, and larger studies in children are lacking. We performed a retrospective study of all sequential pediatric patients who underwent a thyroidectomy for a neoplasm at our institution over a twenty-year period in order to explore the link between HT and pediatric thyroid cancer. A total of 153 patients, median age 16.5 (interquartile range [IQR] 14.2–18.3) years, underwent thyroid surgery for a neoplasm. Patients were mainly female (80%) and White (84%). Median follow-up was 58.6 (IQR 20.7–105.4) months. Thirty-five (23%) patients had HT. Patients who underwent thyroid surgery and had HT were more likely to harbor a malignant neoplasm (p= 0.05); specifically, papillary thyroid carcinoma (PTC,p= 0.02). There was a difference in the distribution of HT among the subtypes of PTC (p= 0.03). Despite this, there was no difference in terms of survival between patients with/without HT. In conclusion, children with a thyroid malignancy, specifically, PTC, are more likely to have HT. The association between HT and pediatric PTC appears to be subtype-specific but does not seem to affect patient survival.
桥本甲状腺炎（HT）与儿童甲状腺癌之间的关联存在争议。目前多数相关研究基于成人群体，而针对儿童的大规模研究较为缺乏。为探究HT与儿童甲状腺癌的关系，我们对本机构二十年间所有因甲状腺肿瘤接受甲状腺切除术的连续儿科病例进行了回顾性研究。研究共纳入153例患者，中位年龄16.5岁（四分位距[IQR] 14.2-18.3岁），患者以女性（80%）和白种人（84%）为主。中位随访时间为58.6个月（IQR 20.7-105.4个月）。其中35例（23%）患者伴有HT。接受甲状腺手术的HT患者更可能罹患恶性肿瘤（p=0.05），特别是甲状腺乳头状癌（PTC，p=0.02）。不同PTC亚型中HT的分布存在差异（p=0.03）。尽管如此，伴或不伴HT的患者在生存率方面未见显著差异。结论表明，患有甲状腺恶性肿瘤（特别是PTC）的儿童更可能同时存在HT。HT与儿童PTC的关联具有亚型特异性，但似乎不影响患者生存预后。
Hashimoto’s Thyroiditis and the Risk of Papillary Thyroid Cancer in Children
肿瘤(癌症)患者之家