Increased life expectancy and cancer prevalence rates expose patients to a higher risk of developing other comorbidities such as stroke. This study aimed to evaluate the risk factors for and prognosis of stroke in patients with gynecological cancers. A single-center retrospective cohort study was conducted on patients with cervical, endometrial, and epithelial ovarian cancers. Patients were classified into three groups based on the period of stroke onset: at least one year before cancer diagnosis, within one year before cancer diagnosis to six months after the last treatment date, and six months after the last treatment date. Among the 644 patients, stroke occurred in 54 (8.4%). In univariate analysis, stroke was significantly associated with overall survival. In contrast, in multivariate analysis, stroke was significantly associated with age and hypertension, but not with overall survival. Age, pulmonary thromboembolism/deep vein thrombosis, histological grade, and tumor stage were significantly associated with overall survival. Therefore, it is important to establish an appropriate examination and treatment plan for patients with gynecologic cancers using a multidisciplinary approach that incorporates the patient’s age, medical condition, and tumor characteristics rather than excessively considering the adverse effects of stroke on cancer prognosis.
预期寿命延长与癌症患病率上升使患者面临更高的卒中风险。本研究旨在评估妇科癌症患者发生卒中的危险因素及预后。针对宫颈癌、子宫内膜癌和上皮性卵巢癌患者开展单中心回顾性队列研究，根据卒中发生时间将患者分为三组：癌症确诊前至少一年、癌症确诊前一年至末次治疗后六个月期间、以及末次治疗六个月后。644例患者中共有54例（8.4%）发生卒中。单因素分析显示卒中与总生存期显著相关，而多因素分析表明卒中与年龄和高血压显著相关，但与总生存期无显著关联。年龄、肺血栓栓塞/深静脉血栓形成、组织学分级和肿瘤分期与总生存期显著相关。因此，制定妇科癌症患者的诊疗方案时，应通过多学科协作模式综合考虑患者年龄、身体状况及肿瘤特征，而非过度关注卒中对癌症预后的负面影响。
Risk Factors and Prognosis of Stroke in Gynecologic Cancer Patients
肿瘤(癌症)患者之家