Brain malignancies, given their intricate nature and location, present significant challenges in both diagnosis and treatment. This review critically assesses a range of diagnostic and surgical techniques that have emerged as transformative tools in brain malignancy management. Fast biopsy techniques, prioritizing rapid and minimally invasive tissue sampling, have revolutionized initial diagnostic stages. Intraoperative flow cytometry (iFC) offers real-time cellular analysis during surgeries, ensuring optimal tumor resection. The advent of intraoperative MRI (iMRI) has seamlessly integrated imaging into surgical procedures, providing dynamic feedback and preserving critical brain structures. Additionally, 5-aminolevulinic acid (5-ALA) has enhanced surgical precision by inducing fluorescence in tumor cells, aiding in their complete resection. Several other techniques have been developed in recent years, including intraoperative mass spectrometry methodologies. While each technique boasts unique strengths, they also present potential limitations. As technology and research continue to evolve, these methods are set to undergo further refinement. Collaborative global efforts will be pivotal in driving these advancements, promising a future of improved patient outcomes in brain malignancy management.
鉴于脑部恶性肿瘤的复杂性质及所处位置，其在诊断与治疗方面均面临重大挑战。本文综述了一系列在脑恶性肿瘤诊疗中具有变革意义的诊断与外科技术。快速活检技术以快速、微创的组织取样为优先原则，彻底革新了初始诊断阶段。术中流式细胞术可在手术过程中提供实时细胞分析，确保肿瘤切除的最优化。术中磁共振成像的出现将影像学无缝整合至外科手术中，提供动态反馈并保护关键脑组织结构。此外，5-氨基乙酰丙酸通过诱导肿瘤细胞产生荧光，提高了手术精准度，有助于实现肿瘤的完整切除。近年来还涌现出包括术中质谱分析在内的多种新技术。尽管每种技术都具有独特优势，但也存在潜在局限性。随着技术与研究的持续发展，这些方法将不断得到完善。全球协作努力对于推动这些技术进步至关重要，有望为脑恶性肿瘤治疗带来更佳的患者预后前景。
肿瘤(癌症)患者之家