With the emergence of novel variants, there have been widespread COVID-19 infections in the Chinese mainland recently. Compared to ancestral COVID-19 variants, Omicron variants become more infectious, but less virulent. Previous studies have recommended postponing non-emergency surgery for at least 4–8 weeks after COVID-19 infection. However, delayed surgery has been shown to be associated with tumor progression and worse overall survival for cancer patients. Here, we examined surgery risk and optimal timing for colorectal cancer patients with perioperative COVID-19 infection. A total of 211 patients who underwent colorectal cancer surgery from 1 October 2022 to 20 January 2023 at Xinhua Hospital were included. In addition, COVID-19-infected patients were further categorized into three groups based on infected time (early post-COVID-19 group, late post-COVID-19 group and postoperative COVID-19 group). The complication rate in patients with COVID-19 infection was 26.3%, which was significantly higher than in control patients (8.4%). The most common complications in COVID-19-infected patients were pneumonia, ileus and sepsis. Patients who underwent surgery close to the time of infection had increased surgery risks, whereas surgery performed over 1 week after recovery from COVID-19 did not increase the risk of postoperative complications. In conclusion, surgery performed during or near the time of COVID-19 infection is associated with an increased risk of developing postoperative complications. We recommend that the safe period for patients with recent COVID-19 infection in colorectal cancer surgery be at least 1 week after recovery from COVID-19.
随着新冠病毒新型变异株的出现，近期中国大陆地区出现了广泛的新冠病毒感染。与早期新冠病毒变异株相比，奥密克戎变异株具有更强的传染性，但致病性有所减弱。既往研究建议将非急诊手术推迟至新冠病毒感染后至少4-8周进行。然而，延迟手术已被证实与肿瘤进展及癌症患者总体生存率降低相关。本研究旨在探讨围手术期感染新冠病毒的结直肠癌患者的手术风险及最佳手术时机。我们纳入了2022年10月1日至2023年1月20日期间在新华医院接受结直肠癌手术的211例患者。根据感染时间将新冠病毒感染患者进一步分为三组（新冠感染早期组、新冠感染晚期组及术后感染组）。新冠病毒感染患者的并发症发生率为26.3%，显著高于对照组患者的8.4%。新冠病毒感染患者最常见的并发症为肺炎、肠梗阻和败血症。在感染时间附近接受手术的患者手术风险增加，而在新冠病毒感染康复1周后进行手术并未增加术后并发症风险。综上所述，在新冠病毒感染期间或临近感染期进行手术与术后并发症风险增加相关。我们建议近期感染新冠病毒的结直肠癌患者的安全手术时机应为新冠病毒感染康复后至少1周。
肿瘤(癌症)患者之家