文章：

果蝇中力学与Hippo信号通路的相互作用

The Interaction of Mechanics and the Hippo Pathway inDrosophila melanogaster

原文发布日期：3 October 2023

DOI: 10.3390/cancers15194840

类型: Article

开放获取: 是

英文摘要：

Drosophila melanogasterhas emerged as an ideal system for studying the networks that control tissue development and homeostasis and, given the similarity of the pathways involved, controlled and uncontrolled growth in mammalian systems. The signaling pathways used in patterning theDrosophilawing disc are well known and result in the emergence of interaction of these pathways with the Hippo signaling pathway, which plays a central role in controlling cell proliferation and apoptosis. Mechanical effects are another major factor in the control of growth, but far less is known about how they exert their control. Herein, we develop a mathematical model that integrates the mechanical interactions between cells, which occur via adherens and tight junctions, with the intracellular actin network and the Hippo pathway so as to better understand cell-autonomous and non-autonomous control of growth in response to mechanical forces.

摘要翻译： 

黑腹果蝇已成为研究控制组织发育与稳态网络的理想模型系统，鉴于其信号通路与哺乳动物系统的相似性，该模型同样适用于研究哺乳动物系统中受控与失控的生长过程。果蝇翅盘模式形成所涉及的信号通路已较为明确，这些通路与Hippo信号通路的相互作用逐渐显现，而Hippo通路在调控细胞增殖与凋亡中起着核心作用。力学效应是生长调控的另一关键因素，但其作用机制尚不明确。为此，我们构建了一个数学模型，该模型通过整合细胞间黏附连接与紧密连接介导的力学相互作用、细胞内肌动蛋白网络及Hippo信号通路，旨在深入理解机械力作用下细胞自主与非自主的生长调控机制。

原文链接：

The Interaction of Mechanics and the Hippo Pathway inDrosophila melanogaster