文章：

胰腺癌分泌蛋白：靶向其在肿瘤微环境中的功能

Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

原文发布日期：1 October 2023

DOI: 10.3390/cancers15194825

类型: Article

开放获取: 是

英文摘要：

Pancreatic Ductal Adenocarcinoma (PDAC) is a ravaging disease with a poor prognosis, requiring a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggest a shift in focus towards the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer-secreted proteins in the complex TME tumor-stroma crosstalk, shedding lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies.

摘要翻译： 

胰腺导管腺癌（PDAC）是一种预后极差的侵袭性疾病，需要对其生物学机制进行更深入的理解以推动有效疗法的开发。针对细胞增殖及其相关机制的治疗方案效果不佳，提示应将研究重点转向炎症性肿瘤微环境（TME）。本文探讨了肿瘤分泌蛋白在复杂的TME肿瘤-间质相互作用中的功能，为开发创新、安全且高效的治疗策略揭示了可成药的分子靶点。

原文链接：

Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment